Project Grant R44GM117961

This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $100,000 to the Georgia Tech Research Corporation to advance protein engineering through a novel interdisciplinary approach combining artificial intelligence (AI) methods and automated laboratory experimentation. The research aims to greatly accelerate the discovery of new proteins with enhanced properties, offering significant potential impact across scientific domains...

This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $730,000 to the University of California, Los Angeles (UCLA) aims to transform the field of protein engineering through the development of an innovative technology called PicnnnShells. PicnnnShells are tiny, hollow particles that can rapidly screen up to one million different protein variations in a single day to identify useful proteins for research, industrial or medical applications. The...

This Project Grant award of $174,984 from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) supports the development of a new artificial intelligence (AI)-based computational framework to improve the accuracy of modeling protein structures from medium-resolution cryo-electron microscopy (cryo-EM) data. The research aims to address challenges in accurately determining protein secondary structures by integrating static quality...

This two-year, $200,000 Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems will fund research at the Long Beach Research Foundation to develop multi-activity proteins for improved carbohydrate deconstruction. Specifically, the Foundation will produce and test 85 engineered multi-activity proteins containing two catalytic domains each. These proteins aim to increase biomass conversion for alternative fuels and...

Phoenix Bioinformatics Corporation was awarded a $617,216 Project Grant from the National Science Foundation Division of Biological Infrastructure. The grant aims to transition MorphoBank to a sustainable, permanent home for phenotypic data in phylogenetics research from July 1, 2021 to June 30, 2024. Under the Biological Sciences program (CFDA 47.074), the company will ensure long-term curation and access to MorphoBank, a digital library of specimen images and data used by evolutionary...

This Project Grant award of $150,000 from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) supports the development of deep learning-based consistency models to enable more efficient and long-duration molecular dynamics simulations of protein dynamics. The key products of this 2-year project, which runs from August 2025 to July 2027, include: Developing prototype consistency models trained on molecular dynamics trajectories...

This Project Grant award of $175,000 from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) supports the development of a modular framework for modeling the binding of peptides and proteins to cell membranes. The key products to be delivered include: A software "mover" implemented in the Rosetta C++ codebase to predict the placement of proteins and peptides in cell membranes, an application of this mover compatible...

This National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET) Project Grant of $579,734 awarded to Rutgers, The State University, aims to accelerate the design and development of synthetic enzymes through a combination of artificial intelligence, polymer science, and robotics. The project will implement an iterative design-build-test-learn process to reveal the underlying structure-function relationships that can produce enzyme mimetic...

The National Science Foundation (NSF) awarded Pearl Bio, Inc., a biotechnology company, a $274,462 Project Grant under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084). The grant funded the development of a next-generation biomanufacturing platform to engineer new microbial organisms and cellular machinery. This platform enables the incorporation of diverse, non-native components into proteins, creating a new class of biological materials for therapeutic development,...

The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a 3-year, $450,000 Project Grant to The Washington University to develop a novel "Plasmon-Enhanced Expansion Fluorospot" (PEEFS) technology. This bioplasmonic imaging method combines fluorescent nanoparticles and expansion microscopy to enable highly sensitive and high-resolution monitoring of cell-secreted proteins at the single-cell level. Key project objectives...