Project Grant R44GM116193

Partillion Bioscience Corp. was awarded a $659,037 Project Grant from the National Institutes of Health's National Institute of General Medical Sciences to develop reagent products enabling high-throughput screening and selection of single cells based on secreted bio-products. Under the Biomedical Research and Research Training program (CFDA 93.859), Partillion plans to transition its lab-on-a-particle technology—highlighted as a 2020 SLAS Innovation Award winner—into the first reagent product...

Molecular Instruments, Inc. received a $306,788 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for the period September 30, 2025 through September 29, 2026. The award supports the development and advancement of probe technology for ultrasensitive RNA imaging utilizing Hybridization Chain Reaction (HCR) methodology. The company is developing enhanced in situ amplification-based imaging...

The National Cancer Institute (NCI) awarded Pacific Northwest National Laboratory (PNNL), a division of Battelle Memorial Institute, a $450,904 Project Grant under the Cancer Biology Research program (CFDA 93.396) to develop an innovative single-cell (phospho-)proteomics platform for analyzing the tumor microenvironment (TME). The three-year award, active from September 1, 2025 through August 31, 2028, funds the development of technology to address critical limitations in current single-cell...

This $125,805 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop new cell sorting technologies that can identify and separate cells based on changes in the activity of naturally occurring light-emitting molecules like NAD(P)H. The goal is to enable label-free, rapid identification and purification of cell populations, with a focus on stem cells and their functional subsets. The research will create a single cell deposition module to...

This Project Grant award of $432,834 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) with a performance period from April 15, 2025 to March 31, 2028. The objective is to develop an enzyme-free, label-free quantitative microarray technology to accurately measure and quantify small nucleic acid targets such as microRNA in the attomolar range for applications like liquid biopsy. The research...

This $671,072 federal Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) will fund the development of a novel microdevice to measure malignant lipid signaling in single cells from clinical samples. The University of Washington will lead a multidisciplinary collaboration to create a "picoliter thin-layer chromatography" (PTLC) chip and supporting hardware, integrating bioengineering, chemistry, and oncology expertise. This...

This $536,250 Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports computational method development to advance single-cell transcriptomic data analysis. Awarded to Sanford Burnham Prebys Medical Discovery Institute in La Jolla, California, the project runs from July 1, 2025 through June 30, 2027 and develops knowledge-guided algorithms designed to improve the detection and...

This $174,195 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop new cell sorting technologies based on measuring the fluorescence lifetime of the molecule NAD(P)H, which can indicate cell metabolic activity. The primary goals are to (1) create a single-cell deposition module that can identify stem cells within mixed populations based on NAD(P)H fluorescence lifetimes, and (2) separate metabolic subpopulations within stem cell lines...

This federal Project Grant award of $419,133, provided by the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394), supports the development of the AscitesPredict technology. AscitesPredict is a novel "ex vivo tumor biosensor" that leverages single-cell technologies to evaluate cell identities and therapeutic sensitivities in patient ascites samples, which are often discarded despite being a plentiful and representative tumor source. The...

The National Science Foundation (NSF) awarded a $300,000 Project Grant under its Biological Sciences program (CFDA 47.074) to the Georgia TECH Research Corporation for the "TOOLS4CELLS: EAGER: A MOLECULAR PURSUIT FOR THE ENGRAM: MICROFLUIDIC TEMPORAL TRANSCRIPTOMICS FOR SINGLE CELL LEARNING" project. This 2-year effort aims to develop innovative microfluidic tools and workflows to investigate the role of non-coding RNA in learning and memory storage in single-celled organisms. Key...