This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $400,835 to Cambium Oncology LLC to develop a novel "armored" CAR-T immunotherapeutic for treating pancreatic ductal adenocarcinoma (PDAC). The aim is to engineer CAR-T cells that target MUC16, a marker abundant in PDAC tumors, and secrete an optimized VIP receptor antagonist to disrupt the immunosuppressive tumor microenvironment. The 1-year project will validate the VIP antagonist for secretion by CAR-T cells (Phase 1) and evaluate the toxicity, biodistribution, and mechanism of action of the selected CAR/VIPRA T cells (Phase 2) to prepare for an IND submission. This work leverages a clinically validated CAR target and preliminary data showing enhanced CAR-T cell functionality, potentially revolutionizing PDAC treatment and serving as a platform for other solid tumors.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $400.8k | 4/23/25 |