This $1,377,000 Project Grant award from the National Institutes of Health's Trans-NIH Research Support program (CFDA 93.310) aims to develop a novel oncolytic virus platform called VMG for the treatment of pancreatic ductal adenocarcinoma (PDAC). The key products and services to be delivered under this 3-year project include: Evaluating the VMG oncolytic virus vector's ability to selectively target and destroy PDAC tumor cells while sparing normal tissues, through expression of enzymes to break down the dense tumor stroma. Assessing VMG's potential to enhance tumor immunogenicity and promote anti-tumor immune responses, either as a standalone approach or in combination with immune checkpoint inhibitors. Exploring the use of VMG vectors expressing allogeneic major histocompatibility complex antigens to trigger a potent immune reaction against PDAC tumors. This high-risk, high-reward research from the University of Arkansas for Medical Sciences seeks to advance oncolytic virotherapy approaches and improve treatment outcomes for this deadly form of pancreatic cancer.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.4m | 8/19/24 |