Project Grant R44AG090112

Award Date 9/25/24
Completion Date 5/31/26
Dollars Obligated $1.3M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
North Carolina, USA
Similar Awards
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Epicypher, Inc. provides $1,274,993.00 in funding from August 15, 2024 to April 30, 2026 to develop a new genomic platform called "Reverse Transcribe & Tagmentation (RT & TAG)" for analyzing chromatin-associated RNAs and nascent transcripts. The key products and services to be delivered under this grant include: Optimizing RT & TAG to study polyadenylated...
This $500,000 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) will support Sxrna Technologies, Inc. in developing an organoid toolkit for Alzheimer's disease (AD) and Alzheimer's-disease-related dementias (ADRD). The company aims to create a platform for identifying senescent cells in living tissue, which can provide insights into the aging process and enable high-throughput drug screening in complex 3D tissue models. Specifically, the grant will fund...
This $1,044,855 Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund Nemalife Inc. to deliver high-throughput testing of anti-aging and FDA-approved drugs in genetically diverse invertebrate Alzheimer's disease models. Under the Aging Research program (CFDA 93.866), the awardee will screen 300 anti-aging compounds and 200 FDA drugs to identify candidates that improve neuronal aging and protect against protein misfolding diseases...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $652,286 Project Grant to Northeastern University. The grant, titled "Genome-Wide CRISPR Activation: A Novel Strategy for Identifying Anti-Aging Targets," aims to systematically identify genes that modulate lifespan and health in the model organism C. elegans using advanced CRISPR activation technology. The research team, with expertise in aging genetics and high-throughput...
The National Institute on Aging (NIA) awarded a $400,000 project grant (CFDA 93.866 - Aging Research) to The Trustees of the University of Pennsylvania, effective from September 15, 2024 to August 31, 2025. The grant supports the development of computational methods to measure epigenetic, transcriptomic, and splicing noise as indicators of cellular aging and senescence. The research aims to establish quantitative profiles of cellular aging and understand how gene dysregulation, senescence, and...
This Project Grant award, valued at $125,896.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to conduct research on Alzheimer's disease (AD) risk and resilience pathways. The objective is to leverage state-of-the-art single-nuclei multi-omic functional genomic analyses of healthy and AD human brain tissue, as well as transgenic AD mouse models, to perform deep molecular characterization of AD risk and resilience across...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,041,438 to develop new computational tools and biomarkers for Alzheimer's disease. The University of Miami will aggregate and analyze DNA methylation datasets to identify age-associated epigenetic changes related to aging and Alzheimer's progression. Researchers will create a searchable web interface to disseminate findings on the role of DNA...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $506,404.00 to The Trustees of the University of Pennsylvania for a research project investigating the role of epigenetic mechanisms in aging and age-related diseases. The key objectives are to: (1) examine how changes in enhancer regulation and chromatin organization during senescence drive gene expression patterns; (2) elucidate the mechanisms underlying inappropriate "cryptic"...
The National Institute on Aging (NIA) awarded a $619,681 Project Grant (CFDA 93.866 - Aging Research) to The Leland Stanford Junior University (Stanford University) to develop a toolkit called "Combo-Seq/Tag" that combines gene editing techniques and protein tagging for studying Alzheimer's disease (AD) risk genes and pathways in human stem cell and mouse models. The project aims to provide innovative gene editing vectors and multi-omics datasets to help elucidate the complex genetic...
The federal Project Grant award R21AG091356 for $423,994.00, awarded by the National Institute on Aging under the Aging Research program (CFDA 93.866), will support research at Duke University to characterize spatial variations in RNA isoform expression associated with Alzheimer's disease (AD). The multi-omic approach will leverage single-nucleus cDNA, long-read RNA sequencing, and in situ sequencing to profile isoform expression at single-cell resolution in the inferior frontal gyrus, a...

This Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) provides funding of $1,274,632.00 to Epicypher, Inc. to develop CUTANA-RH, a novel technology platform for genome-wide profiling of R-loops to accelerate aging and neurodegenerative disease research. The key innovations include a modular immunotethering strategy utilizing a catalytically inactive RNase H1 enzyme, as well as the development of designer nucleosome spike-in controls. Phase II of the project will focus on optimizing the CUTANA-RH workflows, validating the assays in cell and tissue models, scaling manufacturing, and demonstrating the platform's capabilities for clinical applications in Alzheimer's disease research. This project aims to provide a highly sensitive, scalable, and reliable method for mapping R-loops, which are associated with DNA damage, genome instability, and neurodegenerative diseases.

Generated 4/29/25, 3:18 AM