Project Grant R44AG054405

This $2,166,172 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) supports the development of novel functional magnetic resonance imaging (fMRI)-based biomarkers for Alzheimer's disease (AD). The project aims to create computationally efficient Bayesian techniques to extract precise functional brain features from individual fMRI scans, without the need for prolonged data collection. These methods will leverage population-derived priors and advanced image...

This Project Grant award, funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to systematically characterize the functional connectivity of white matter in the brain as it relates to typical aging, mild cognitive impairment (MCI), and Alzheimer's disease (AD) progression. The $1,812,929 award, with a performance period from August 1, 2024 to April 30, 2029, will be used by the New Jersey Institute of Technology (NJIT) to investigate white...

The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), awarded a $287,526 Cooperative Agreement under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative program (CFDA 93.372) to The General Hospital Corporation (doing business as Massachusetts General Hospital) to support the Connectome 2.0 project. The Connectome 2.0 project aims to develop and disseminate an ultra-high...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $476,993 to Yale University to develop innovative techniques for measuring white matter hyperintensity (WMH), an important biomarker of stroke and Alzheimer's disease risk, using low-field portable MRI (PMRI) technology. The project aims to create a qualitative WMH grading scale...

This $2,576,654 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support the development of a cloud-based software platform and advanced computational pipelines to harmonize and integrate spatial transcriptomics data for the construction of a spatially resolved brain atlas. Key objectives of the 3-year project include: 1) Creating a cloud-based platform to standardize the analysis and visualization of...

The University of North Carolina at Chapel Hill will develop computational tools to harmonize multi-site neuroimaging data and enable personalized analysis of subjective cognitive decline and Alzheimer's disease-related disorders through a $2.8 million project grant from the National Institute on Aging. Under the award effective May 1, 2022, UNC-Chapel Hill will create machine learning frameworks for feature-level and image-level harmonization of data from 79 imaging centers involving over...

The U.S. National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $1,705,580 Cooperative Agreement under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) program to The Johns Hopkins University. The funding will support the "BRAIN CONNECTS: A SCALABLE AUTOMATED PROOFREADING FRAMEWORK FOR CONNECTOMICS" project from August 2024 through July 2027. The project aims to develop innovative imaging technologies and...

The National Institute of Mental Health (NIMH) awarded a $380,375 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Ceretype Neuromedicine Inc. to design and develop an advanced functional MRI (fMRI) software platform as a medical device for clinical trials and therapeutic applications in neuropsychiatry. The key objectives are to 1) engineer an fMRI system that meets regulatory requirements for industry-backed trials, and 2) establish standard quantitative fMRI measurements,...

This $233,250 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports a 2-year study to establish the feasibility and reproducibility of advanced hyperpolarized 13C pyruvate MRI imaging of the human brain on a major clinical MRI platform (Siemens). The study aims to first test the technique in vitro using a human-scale 3D-printed phantom model, then evaluate the reproducibility of in vivo hyperpolarized 13C pyruvate brain imaging in a cohort of...

This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $722,070 to the University of Massachusetts to develop advanced multimodal imaging biomarkers for frontotemporal dementia (FTD). The key products and services to be delivered include: The research team will leverage expertise in magnetic resonance imaging (MRI)-based thalamic nuclei segmentation and positron emission tomography (PET) super-resolution techniques...