Project Grant R43TR005330

Award Date 7/1/25
Completion Date 6/30/26
Dollars Obligated $350K
Federal Grant Program
93.350
Assistance Type
Project Grant
Place of Performance
Connecticut, USA
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This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, provides $1,640,169 to Synvivia, Inc. to validate a platform for identifying cyclic peptides that can dramatically increase the yield and quality of adeno-associated virus (AAV) vectors manufactured for gene therapy. The key objectives are to: 1) demonstrate that Synvivia's cyclic peptide discovery library contains peptides that...
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This Project Grant award from the National Center for Advancing Translational Sciences (NCATS), under CFDA 93.350, provides $349,909 to Nanoengineering Corporation to develop a viral vector sizing tool to improve gene therapy analytics and reduce drug development costs. The key products and services being delivered include:

  1. Establishing a reproducible protocol for analyzing adeno-associated virus (AAV) serotypes and genomic cargos using Nanoengineering's proprietary electrospray differential mobility analysis (ES-DMA) method. This will enable better monitoring and purification of viral vectors to improve safety and efficacy of gene therapies.

  2. Confirming the correlation between particle mass and size measured by ES-DMA compared to the gold-standard charge detection mass spectrometry, targeting a 95% confidence interval. This will help establish ES-DMA as a novel quality control method for AAV analytics.

  3. Deploying a prototype "NanoRanger" instrument to Vector Biolabs' AAV production facility for on-site beta testing, with the goal of commercializing NanoRanger as a new standard for viral vector characterization. This is expected to enable cost reductions by improving downstream purification processes and upstream production monitoring.

The award period is from July 1, 2025 to June 30, 2026.

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