Project Grant R43NS132623
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $3,565,780 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop a groundbreaking high-frequency trans-spinal magnetic stimulation (HF-TSMS) system for the non-invasive treatment of neuropathic pain. The funded project aims to create an HF-TSMS tool that can target neural pathways involved in...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
- Grant Award Summary This $200,000 Project Grant awarded by the National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) supports research conducted by the University of Maryland, Baltimore to investigate the neurobiological mechanisms by which green light-emitting diode (GLED) therapy reduces chronic pain and anxiety. The research project, initiated on September 12, 2025, with a completion date of May 31, 2030, will deliver scientific...
- This $591,122 Project Grant was awarded on August 1, 2025, by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. Massachusetts Institute of Technology will conduct a four-year research project extending through July 31, 2029, to decode and modulate the emotional component of pain through investigation of autonomic responses and central amygdala neural circuits. The...
- This $1,559,917 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to develop a topical neurokinin-1 receptor (NK1R) antagonist as a non-addictive analgesic treatment for chronic ocular pain. The key objectives are to assess the analgesic efficacy of the NK1R antagonist and determine its effects on the ocular surface-trigeminal ganglion neurosensory pathway. The project is...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $399,870 to 2Morrow Inc. to accelerate the commercialization and dissemination of their evidence-based digital behavioral therapeutic for individuals with chronic pain. The funding will be used to hire a fractional Chief Commercial Officer (CCO) to review and validate 2Morrow's commercialization plan, and then execute a...
- The University of Miami is conducting a research project under a $1,109,446 Cooperative Agreement awarded by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH). The project, funded through the Drug Abuse and Addiction Research Programs (CFDA 93.279), aims to develop a novel non-opioid analgesic based on gene therapy targeting the carbonic anhydrase-8 (CA8) protein to treat chronic pain associated with knee osteoarthritis. The...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $444,125 in funding to Duke University to explore the role of the LRRC55 regulatory protein in pain pathways. The key objectives are to: 1) delineate LRRC55's function in chronic pain behaviors using genetically-modified mice, 2) quantify changes in LRRC55 expression in dorsal root ganglion and spinal cord neurons...
- This federal Project Grant award for $560,934, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to investigate neural coding and control of pain detection in the somatosensory cortex. The key objectives are to: 1) define the temporal patterns and...
- Federal Project Grant Award Summary The University of Pittsburgh received a $402,316 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, awarded on June 12, 2025, with a completion date of February 29, 2028. This research project, titled "Targeting Spinal Orexins to Treat Chronic Pain," will deliver fundamental neuroscience research...
OPTOGENETIC PAIN MODULATOR FOR NON-OPIOID CHRONIC PAIN MANAGEMENT - PROJECT SUMMARY/ABSTRACT: THE MOST COMMON NOTICEABLE SYMPTOM OF DISEASE AND INJURY IS PAIN. IT CAN WARN OF DANGER OR THE NEED TO TREAT A PROBLEM, HOWEVER, WHEN IT BECOMES CHRONIC, IT CAN BECOME DEBILITATING. CHRONIC PAIN IS ESTIMATED TO AFFECT UP TO A THIRD OF THE GLOBAL ADULT POPULATION(MAJEED ET AL., 2018). COMPLICATIONS FROM PAIN TREATMENT CONTINUE TO CAUSE ADDICTION AND INJURY (INCLUDING DEATH). ALTERNATIVE METHODS FOR TREATING CHRONIC PAIN (ESPECIALLY THAT RECALCITRANT TO TREATMENT) IS CRITICAL TO ADDRESSING BOTH CHRONIC PAIN ITSELF AND MITIGATING THE HAZARDS OF LONG-TERM ADMINISTRATION OF CURRENT TREATMENT METHODS. AS IS SEEN IN THE ONGOING OPIOID CRISIS AND THE MASSIVE COSTS OF CHRONIC PAIN TREATMENTS, THE CONSEQUENCES OF UNTREATED PAIN AND TREATMENT THAT LACKS SPECIFICITY CAN BE DIRE. THIS RESULTS IN A LOSS OF QUALITY OF LIFE AND PRODUCTIVITY. OPTOGENETICS OFFERS THE POSSIBILITY FOR BOTH HIGHLY SPECIFIC AND CUSTOMIZABLE CONTROL OF CELLULAR ACTIVITIES, OPENING PATHWAYS FOR TREATMENTS THAT REDUCE RISKS VIA CELLULAR SPECIFICITY WHILE ALSO ALLOWING PERSONALIZED THERAPIES. CURRENTLY, THE MOST COMMON OPSINS REQUIRE AN EXCESSIVE AMOUNT OF POWER TO BE ACTIVATED OR ARE SENSITIVE TO WAVELENGTHS OF LIGHT THAT CAN DAMAGE TISSUES, THUS LIMITING THEIR UTILITY IN MEDICAL TREATMENTS. TO ADDRESS THESE LIMITATIONS, WE HAVE DEVELOPED A UNIQUE SENSITIVE OPSIN AND A STIMULATION DEVICE WHICH CAN PROVIDE TARGETED AND TAILORED ACTIVATION OF THE OPSIN. MULTI- CHARACTERISTIC OPSIN (MCO) CAN BE DELIVERED TO NEURONS INVOLVED IN THE SENSATION AND PROCESSING OF PAIN AND STIMULATED AS NEEDED TO MINIMIZE PAIN PERCEPTION. PRELIMINARY RESEARCH HAS ESTABLISHED THE BASELINE PARAMETERS FOR OPTOGENETIC MODULATION OF PAIN, AND OUR CONTINUED RESEARCH ESTABLISHES THE VALUE AND SAFETY OF THIS APPROACH FOR PAIN MANAGEMENT. TO FURTHER THE CHARACTERIZATION AND OPTIMIZATION OF OUR APPROACH, WE PLAN TO PERFORM THE FOLLOWING AIMS: AIM 1: OPTIMIZE OPM OPTICAL DELIVERY AND TRANSDERMAL/WIRELESS OPTOGENETIC STIMULATION DEVICE. AIM 2: OPTIMIZE THE EFFICACY OF THE MODULATOR AND OPSIN CONSTRUCT FOR SAFE LONG-TERM TREATMENT OF PAIN. SUCCESSFUL DEVELOPMENT HOLDS THE PROMISE TO REVOLUTIONIZE PAIN THERAPY THROUGH A HIGHLY SPECIFIC, PERSONALIZED APPROACH TO PAIN MITIGATION WITH REDUCED HAZARDS AND ENHANCED REWARDS. THIS NOVEL OPTOGENETIC TREATMENT COULD BE APPLIED TO SEVERAL CHRONIC PAIN SYNDROMES WITH POTENTIAL APPLICATIONS FOR OTHER NEUROLOGICAL CONDITIONS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 6/24/25 | ||
| Not listed | $327.9k | 7/17/23 |