Project Grant R43MH143510
- The National Institute of Mental Health awarded $852,247 to the University of Pennsylvania on August 13, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop a networked trial emulation framework for generating real-world evidence on the causal effects of glucagon-like-peptide-1 receptor agonists on mental health outcomes. The project addresses methodological challenges in estimating causal effects of GLP-1 receptor agonists on neuropsychiatric health, including...
- The National Institute of Mental Health awarded Beth Israel Deaconess Medical Center, Inc. $2.961 million on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop standardized digital health data formats for mental health research and clinical care. The award funds five integrated aims. Aim 1 establishes a multidisciplinary consortium of clinicians, researchers, industry representatives, regulators, and patient advocates to develop a governance framework...
- The National Institute of Mental Health awarded Miresource, Inc. $1.744 million on September 12, 2025, under the Mental Health Research Grants program (CFDA 93.242) to develop a longitudinal mental health monitoring platform that generates personalized care guides and treatment referrals. Miresource will integrate software solutions, curate mental health content, and employ artificial intelligence to create personalized guides and automate triage and referral recommendations. The project aims to...
- The National Institute of Mental Health awarded the University of Pittsburgh $739,727 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop federated statistical harmonization and multivariate modeling frameworks for investigating altered brain aging patterns in individuals with severe mental illness and the modifying effects of metabolic syndrome. The project addresses methodological challenges in large-scale neuroimaging research by leveraging the ENIGMA...
- The National Institute of Mental Health awarded New York University $435,974 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop computational models that quantify individual differences in learning and decision-making and predict psychiatric symptoms. The award funds development of a novel computational framework combining recurrent neural networks and dynamical systems theory to model reward learning processes at the individual level rather than group...
- The National Institute of Mental Health awarded $456,902 to 37Degrees, Inc. on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop INVITREON, a compact integrated platform for long-term neuronal culture incubation, recording, and closed-loop stimulation. The project runs through July 31, 2028, with performance in Chicago, Illinois. INVITREON addresses technical barriers in microelectrode array (MEA) culture systems used for disease modeling, neurotoxicity...
- The National Institute of Mental Health awarded $442,750 to the University of California, Davis on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop statistical methods for predicting individualized intervention effects in clustered and longitudinal datasets. The project addresses a critical gap in precision medicine: identifying individuals likely to respond to specific interventions when dealing with high-dimensional biomarker data and complex data...
- The National Institute of Mental Health awarded Northeastern University $157,500 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to explore the role of microglia in developmental effects of early life adversity on prefrontal cortex glutamate receptor development. The research investigates how microglia, resident immune cells of the brain, drive changes in NMDA receptor expression in adolescents exposed to early life adversity such as maternal separation. Prior...
- The National Institute of Mental Health awarded The General Hospital Corporation (Massachusetts General Hospital) $824,404 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop machine learning models that integrate clinician-conducted suicide risk assessments with electronic health record data to improve prediction of suicidal behavior and guide precision interventions in outpatient behavioral health settings. The research leverages routine clinical...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $722,773 under the Mental Health Research Grants program (CFDA 93.242) on July 15, 2026, to develop explainable artificial intelligence frameworks for predicting depression incidents in people with HIV. The research integrates multimodal data from 3,962 people with HIV across multiple longitudinal studies to elucidate bidirectional associations between HIV, depression, and immune dysregulation. The project...
The National Institute of Mental Health awarded Ividence Inc. $315,276 on August 5, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop a federated causal inference framework for evaluating the mental health effects of glucagon-like peptide-1 receptor agonists (GLP-1 RAs). The project will produce a privacy-preserving, multi-site analytical framework and accompanying R software package to generate real-world evidence on neuropsychiatric outcomes from GLP-1 RA treatment. Aim 1 develops a federated target trial emulation model that produces pooled causal estimates using only summary statistics, integrating sequential trial emulation, exposure correction, and negative control outcome calibration without requiring centralized data sharing. Aim 2 evaluates the framework using de-identified electronic health record data from Ividence and UT Southwestern Medical Center, delivers a prototype R package with tools for data preprocessing, federated estimation, and visualization, and assesses feasibility through analytic performance, system usability, and concordance with benchmark evidence. The framework is designed to address confounding, exposure misclassification, and institutional data-sharing barriers that have hindered prior observational studies in mental health research. Work is performed in Newark, Delaware. The period of performance runs from the award date through July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $315.3k | 8/7/26 |