Project Grant R01MH142790
- The National Institute of Mental Health awarded Ividence Inc. $315,276 on August 5, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop a federated causal inference framework for evaluating the mental health effects of glucagon-like peptide-1 receptor agonists (GLP-1 RAs). The project will produce a privacy-preserving, multi-site analytical framework and accompanying R software package to generate real-world evidence on neuropsychiatric outcomes from GLP-1 RA...
- The National Institute of Mental Health awarded the University of Pittsburgh $1,004,971 through the Mental Health Research Grants program (CFDA 93.242) on April 8, 2026, to develop a platform for measuring and analyzing brain activity, cognitive states, behavior, and physiology during multiday neural recordings in individuals undergoing surgical treatment for epilepsy. The project will integrate wearable technology and artificial intelligence for behavioral and physiological monitoring alongside...
- The National Institute of Mental Health awarded The Trustees of The University of Pennsylvania $200,538 on December 14, 2025, under the Mental Health Research Grants program (CFDA 93.242) to investigate functional cortical development and its relationship to transdiagnostic psychopathology risk. The recipient will map the functional organization of the cortex across development using a normative modeling framework applied to four large-scale developmental datasets: the Philadelphia...
- The National Institute of Mental Health awarded the University of Pittsburgh $739,727 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop federated statistical harmonization and multivariate modeling frameworks for investigating altered brain aging patterns in individuals with severe mental illness and the modifying effects of metabolic syndrome. The project addresses methodological challenges in large-scale neuroimaging research by leveraging the ENIGMA...
- The National Institute of Mental Health awarded The Trustees of the University of Pennsylvania $110,228 under the Mental Health Research Grants program (CFDA 93.242) on November 4, 2026, to map person-specific and spatially precise white matter development to transdiagnostic psychopathology and polygenic risk in adolescents. The research characterizes within-individual, along-tract white matter development in relation to transdiagnostic psychiatric symptoms and evaluates whether associations are...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded the University of Pennsylvania a $2,693,038 Project Grant under the Mental Health Research Grants program (CFDA 93.242) for the period September 1, 2025 through August 31, 2029. The award funds research investigating the role of striatal interneurons in behavioral control and value-based decision-making. The project will employ viral-genetic tools and a head-fixed, value-based choice task to systematically examine...
- The National Institute of Mental Health awarded the University of Pittsburgh $728,751 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the neural mechanisms by which antidepressant placebo effects modulate mood in patients with major depressive disorder. The research dissects expectancy-driven dynamics between the salience network and default mode network using theta burst stimulation in a 200-patient, randomized, factorial design. The study...
- The National Institute of Mental Health awarded New York University $435,974 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop computational models that quantify individual differences in learning and decision-making and predict psychiatric symptoms. The award funds development of a novel computational framework combining recurrent neural networks and dynamical systems theory to model reward learning processes at the individual level rather than group...
- The National Institute of Mental Health awarded The Trustees of The University of Pennsylvania $762,440 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and validate a concurrent transcranial magnetic stimulation and functional MRI protocol for measuring the effects of continuous theta burst stimulation to the right dorsolateral prefrontal cortex on anxiety-related neural and behavioral responses. The protocol will assess TMS-evoked BOLD responses and...
- The National Institute of Mental Health awarded Northeastern University $157,500 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to explore the role of microglia in developmental effects of early life adversity on prefrontal cortex glutamate receptor development. The research investigates how microglia, resident immune cells of the brain, drive changes in NMDA receptor expression in adolescents exposed to early life adversity such as maternal separation. Prior...
The National Institute of Mental Health awarded $852,247 to the University of Pennsylvania on August 13, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop a networked trial emulation framework for generating real-world evidence on the causal effects of glucagon-like-peptide-1 receptor agonists on mental health outcomes. The project addresses methodological challenges in estimating causal effects of GLP-1 receptor agonists on neuropsychiatric health, including measurement errors, immortal time bias, incomplete drug adherence data, and fragmented multi-institutional data sources. The framework integrates systematic-error correction techniques, federated learning, natural language processing-enhanced phenotyping, and tensor train decomposition to enable scalable multi-institutional causal inference and accurate drug adherence and mental health phenotyping from structured and unstructured clinical data. Performance occurs in Philadelphia, Pennsylvania, with a period of performance through May 31, 2031. The award is classified as a Project Grant with assistance type R01MH142790.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $852.2k | 8/17/26 |