This $449,228 Project Grant, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), will fund the development of an integrated system for long-term electrophysiological profiling of human brain organoids. The key products to be delivered are:
A biological assay chamber that supports chronic electrophysiology while maintaining organoid health;
High-fidelity, 3D neural probes for chronic, extracellular recording and stimulation;...
This Project Grant award of $1,038,154 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports the development of a dual-function microelectrode probe that can simultaneously measure neurochemical and electrophysiological activity in the nervous system. The principal investigator, Dr. Alexander Zestos, is partnering with Spike Neuro LLC to refine carbon deposition processes for Spike Neuro's silicon microelectrodes and explore...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, was awarded to Intelligent Imaging Innovations, Inc. (3i) to establish the feasibility of developing a commercial instrument for large-scale, all-optical electrophysiology. The $505,311 award, spanning January 1, 2025 to December 31, 2026, seeks to combine recent advancements in optical techniques, such as volumetric imaging of neural activity and...
The National Institute of Mental Health (NIMH) awarded a $517,546 Project Grant (CFDA 93.242 Mental Health Research Grants) to Trustees of Dartmouth College to develop a novel multimodal microelectrode array (MEA) probe with integrated fast-scan cyclic voltammetry (FSCV) for sub-second neuromodulator sensing and parallel electrophysiological recording. This 5-year award, running from December 2024 to October 2029, aims to optimize, benchmark, and validate the EPHYS-FSCV MEA platform for...
The National Institute of Mental Health (NIMH) awarded a $560,641 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Psychogenics Inc. to develop an innovative drug repurposing platform using electroencephalogram (EEG) data. The goal is to create an EEG-based screening platform, called eCube, that can compare EEG signatures of reference drugs against animal models of rare diseases to rapidly identify potential drug repurposing opportunities. The Phase I proof-of-concept project...
This U.S. National Institute of Mental Health (NIMH) Project Grant award under the Mental Health Research Grants program (CFDA 93.242) provides $790,443 to Mcmaster University in Canada to develop a user-friendly, open-source software pipeline for analyzing single-trial magnetoencephalography (M/EEG) brain activity data. The award aims to make recent innovations in M/EEG analysis techniques, such as continuous time modeling and improved source localization, more accessible to a broad audience...
This federal Project Grant award from the National Institute of Mental Health (NIMH) - Mental Health Research Grants program (CFDA 93.242) provides $2,031,463.00 to develop an advanced technology for non-invasive recording of whole-brain physiology with synchronized video-tracking of movement for use in children with intellectual disability.
The award supports two key objectives: 1) Refining and validating the use of the wearable FieldLine HEDscan optically-pumped magnetometer...
The Project Grant award R43MH135772, totaling $300,691.00, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The award aims to advance Numentus Technologies Inc.'s high-speed hyperspectral imaging technology for highly multiplexed immunofluorescence imaging in pathology. The project will improve the company's technology to enable rapid, cost-effective detection of up to 12 molecular targets in a single tissue sample,...
This $1,596,935 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports the commercialization of Petcoil, Inc.'s portable, brain-dedicated positron emission tomography (PET) insert system that can be used in existing magnetic resonance imaging (MRI) machines. The goal is to develop a lower-cost solution for simultaneous PET/MRI brain imaging compared to current permanently-integrated PET/MRI systems, which...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $446,490 to Esperimage LLC to develop flexible and scalable photogrammetric head modeling tools to complement their wearable, high-fidelity optical brain imaging technology. The goal is to enable naturalistic brain imaging studies, particularly in children with autism spectrum disorder, to overcome the limitations of previous neuroimaging...