This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $304,119 to Endomimetics LLC to develop innovative in vitro models and assays for screening atherosclerosis treatments. The goal is to create a highly automated, precise approach for fabricating 3D vascular sheets and atherosclerosis models to enable efficient, high-throughput drug testing in a human-relevant environment. Specifically,...
This Project Grant from the National Heart, Lung and Blood Institute, part of the Department of Health and Human Services, provides $920,176 under the Cardiovascular Diseases Research program to develop a smart aspiration catheter with fiber optic pressure sensors for mechanical thrombectomy procedures to treat acute ischemic stroke. The catheter will be designed, prototyped and validated at Worcester Polytechnic Institute to provide real-time data to interventionalists on the interaction...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $295,922 to Pericor LLC to develop a novel medical device called PERISCOPE. The device is designed to enable safer, fluoroscopy-free pericardial access for epicardial ablation procedures, which are essential but challenging steps in the treatment of over 300,000 cardiac ablation patients annually in the United States. The...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $295,892 to Asclepia Technology LLC to conduct a proof-of-concept study on a targeted cellular therapy for treating atherosclerotic vascular disease in minority patients. The funding will support the development and evaluation of dual-functional, echogenic immunoliposomes (DF-ELIP) that can deliver vascular stem cells (VSC) to...
The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837), awarded Nytricx, Inc. a $311,824 project grant to develop an endovascular prosthetic graft device that integrates nitric oxide (NO)-releasing polymer technology. The goal is to create a device that can reduce the incidence of common complications associated with endovascular arterial repair, such as infection, neointimal proliferation, and thrombosis, which often...
The National Institutes of Health's National Heart, Lung and Blood Institute awarded Fluidform Inc. a $766,107 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) from April 1, 2021 to March 31, 2022. The grant funds the development of an advanced bioprosthetic collagen heart valve using 3D printing techniques to recreate the collagen fiber architecture and mechanical properties of native heart valve leaflets. Fluidform will collaborate with Carnegie Mellon...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $497,401 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to 3DT Holdings, LLC, a minority-owned biomedical engineering company. The grant supports the development of a low-profile transcatheter aortic valve implant (TAVR) system. The key objective is to create an advanced TAVR device that utilizes a lower-profile delivery system, which would accommodate a broader patient population and reduce the...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $1,295,800 Project Grant (R21EB034798) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The grant will fund the development of a novel non-rotating nano-optic endoscope capable of providing 360-degree in vivo imaging for applications in the...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $310,170 to Cathpro Technologies, LLC to develop an innovative luminal insert for vascular catheters. The goal is to create a product that combines anti-infective and anti-thrombotic technologies to effectively reduce intraluminal infections and thrombotic occlusions in catheters. The funding will support feasibility studies to optimize...
This Project Grant award of $490,049 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program supports research by Shearit LLC to evaluate the efficacy of their LAMIFLO drag reducing polymer in reducing ischemic core and penumbra volumes and improving neurological recovery in rat models of acute ischemic stroke. The award will fund studies to demonstrate that...