Project Grant R43HL154870

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $583,718 Project Grant to Berendo Scientific LLC under the Cardiovascular Diseases Research program (CFDA 93.837) to optimize and evaluate the SLEEPFLEX head and neck exercise program for the treatment of mild to moderate obstructive sleep apnea (OSA). The project aims to develop a focused, effective, safe, and non-invasive head and neck exercise program delivered via a smartphone app to increase the strength and endurance of key...

The U.S. National Heart Lung and Blood Institute awarded a $316,609 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Remastered Sleep LLC for the development of a "Novel Myofunctional Nipple to Prevent Obstructive Sleep Apnea in Infants." The project aims to address the clear unmet need for a non-invasive, first-line treatment and preventive measure for obstructive sleep apnea (OSA) in infants, which can have detrimental long-term health impacts...

This federal Project Grant award of $449,861 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support a 24-month clinical observational feasibility study on dental practitioners' oral appliance therapy (OAT) titration methods and outcomes for patients with obstructive sleep apnea (OSA). The study will recruit 10 dental practitioners and 60 OSA patients (6 per practitioner) to examine practitioners'...

The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $305,746 Project Grant under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) to Soliish, Inc. The award aims to develop a novel digital platform that uses deep learning to deliver a cost-effective, non-invasive, and user-friendly solution for early detection of obstructive sleep apnea (OSA). The solution, called OSANet, leverages analysis of oral cavity images to predict OSA risk and support...

The University of California, Los Angeles (UCLA) was awarded a $721,237 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to investigate the neural mechanisms by which inspiratory muscle training (IMT) can reduce blood pressure in patients with obstructive sleep apnea. The research project will use resting-state functional magnetic resonance imaging and magnetic resonance spectroscopy to assess changes in insula connectivity and...

This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will validate a new, minimally invasive cervical surgical approach to phrenic nerve stimulation for the treatment of central sleep apnea (CSA). The $982,086 project, awarded to Coridea, LLC, a medical technology firm in New York, aims to develop a simplified procedure that can be performed in an outpatient setting by ENT surgeons, as the current commercially...

This $782,473 federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to improve understanding of the pathogenesis of sleep apnea using novel imaging techniques during sleep. The project aims to characterize the site and pattern of airway collapse as well as how upper airway anatomy mediates this collapse, which could provide new insights to guide optimal therapies, particularly for patients who cannot tolerate...

The National Heart, Lung, and Blood Institute (NHLBI), under CFDA program 93.837 "Cardiovascular Diseases Research", awarded a $1,270,508 Project Grant to the Northern California Institute for Research and Education, Inc. (NCIRE) on September 20, 2025. The grant funds a project titled "Improving Identification of Obstructive Sleep Apnea in Women" that aims to: 1) Identify health factors associated with obstructive sleep apnea in women using electronic health records and...

The University of Washington received a $310,697 Project Grant from the Department of Defense's Military Medical Research and Development program (CFDA 12.420) to conduct research on the use of noninvasive focused ultrasound stimulation of the hypoglossal nerve to treat obstructive sleep apnea. The two-year grant period runs from February 1, 2024 to January 31, 2026. As part of the grant, the University of Washington will investigate this novel treatment approach aimed at improving outcomes...

This Project Grant award, funded by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), aims to study the impact of positive airway pressure (PAP) therapy on myocardial blood flow in adults with obstructive sleep apnea (OSA) at high risk of cardiovascular disease. The $173,556 award to Yale University will recruit 60 individuals with moderate PAP-naive OSA to test the hypotheses that OSA-specific measures of hypoxia and autonomic...