Project Grant R44HL178050
- The National Science Foundation (NSF) awarded a $274,841 Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant to XN Health Inc. on July 15, 2025 to develop a novel transtracheal phrenic nerve stimulation device. This device aims to reduce lung and diaphragm injuries caused by mechanical ventilation, which affects an estimated 1.2 million Americans annually. The project will optimize stimulation parameters, develop an automated algorithm, and validate the system for chronic use in...
- This $782,473 federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to improve understanding of the pathogenesis of sleep apnea using novel imaging techniques during sleep. The project aims to characterize the site and pattern of airway collapse as well as how upper airway anatomy mediates this collapse, which could provide new insights to guide optimal therapies, particularly for patients who cannot tolerate...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $395,306 Project Grant to Cutcath LLC under the Cardiovascular Diseases Research (CFDA 93.837) federal grant program. The grant aims to examine the safety and efficacy of Cutcath's novel Dissection Septum Cutting Catheter (DSCC) device, which is designed to facilitate endovascular treatment of acute aortic dissections. The DSCC uses radiofrequency and a specialized catheter design to completely fenestrate the aortic dissection...
- This $437,461 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), funded under the Cardiovascular Diseases Research program (CFDA 93.837), supports the development of a novel stabilization catheter device for His pacing lead implantation. The goal is to improve the accuracy and ease of His bundle pacing, an emerging alternative cardiac resynchronization therapy (CRT) for heart failure patients. The project aims to refine a deployable suction-tipped lead...
- This federal Project Grant award for $569,695.00, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research into the therapeutic potential of phrenic proprioceptors, or sensory neurons, to restore respiratory function after cervical spinal cord injury. The research, conducted by Marquette University, aims to test the hypothesis that activating these phrenic proprioceptors can induce spinal plasticity and improve breathing...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to elucidate the complex relationship between obstructive sleep apnea (OSA) and cardiovascular disease (CVD). The $1,296,660 award supports a 24-month research project that will employ a "bed to bench" approach integrating clinical, computational, and in vitro techniques. Key objectives include developing and validating a mathematical model to quantify...
- This $323,230 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of a multi-channel radiofrequency and pulsed field energy source generator for cardiac ablation procedures. The award recipient, Sirona Medical Technologies, Inc., is developing a novel catheter device and customizable energy generator to improve the safety and precision of cardiac ablation treatments. Key product features include...
- The National Heart, Lung, and Blood Institute (NHLBI), under CFDA program 93.837 "Cardiovascular Diseases Research", awarded a $1,270,508 Project Grant to the Northern California Institute for Research and Education, Inc. (NCIRE) on September 20, 2025. The grant funds a project titled "Improving Identification of Obstructive Sleep Apnea in Women" that aims to: 1) Identify health factors associated with obstructive sleep apnea in women using electronic health records and...
- This $298,368 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of a novel device for treating mitral valve regurgitation. The project aims to optimize the device design and procedure through bench testing, followed by acute in vivo studies to demonstrate the feasibility of the approach. The funding recipient, Link Medical LLC, has invented a catheter-based technology intended to restore proper mitral...
- The U.S. National Heart Lung and Blood Institute awarded a $316,609 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Remastered Sleep LLC for the development of a "Novel Myofunctional Nipple to Prevent Obstructive Sleep Apnea in Infants." The project aims to address the clear unmet need for a non-invasive, first-line treatment and preventive measure for obstructive sleep apnea (OSA) in infants, which can have detrimental long-term health impacts...
This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will validate a new, minimally invasive cervical surgical approach to phrenic nerve stimulation for the treatment of central sleep apnea (CSA). The $982,086 project, awarded to Coridea, LLC, a medical technology firm in New York, aims to develop a simplified procedure that can be performed in an outpatient setting by ENT surgeons, as the current commercially available device requires a complex, 3-hour thoracic transvascular procedure. By exploiting an accessible anatomical region above the clavicle, this innovative approach seeks to expand treatment options and improve access to phrenic nerve stimulation, the only approved therapy for CSA, which affects an estimated 1% of adults over 40 in the U.S. and is linked to cardiovascular disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/19/25 | ||
| Not listed | $982.1k | 9/11/25 |