Project Grant R43HL139171

Federal Project Grant Award Summary Reneurogen LLC received a $1,045,688 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on September 22, 2025, with completion targeted for June 30, 2027. The award funds development of KYC (N-acetyl-lysyltyrosylcysteine amide), a novel first-in-class drug candidate designed to treat vasculopathy, vasocongestion, vaso-occlusive crisis (VOC), and pain in patients...

Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Children's Research Institute a $3,051,981.02 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a randomized, double-blind, placebo-controlled Phase 2 clinical trial of intravenous L-citrulline for treating vaso-occlusive crisis (VOC) in sickle cell disease patients. The four-year research initiative, commencing May 1, 2025 and concluding April 30, 2029, aims to...

Federal Project Grant Award Summary New Health Sciences, Inc. (doing business as Hemanext Inc.) received a $1,017,232 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) effective September 5, 2025, with completion scheduled for August 31, 2028. The award supports a rigorous clinical efficacy trial evaluating hypoxic red blood cell (HRBC) transfusions processed using the HemaNEXT ONE System compared to...

Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Cincinnati a Project Grant totaling $186,613 (obligated April 10, 2026) under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a five-year neuroimaging research study extending through March 31, 2031. The research deliverables include the measurement and mapping of activated microglia density and distribution in the brains of 45 individuals with sickle cell disease...

Federal Project Grant Award Summary Connecticut Children's Medical Center received a $156,340 project grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded June 15, 2025, with completion targeted by May 31, 2030. This Mentored Patient-Oriented Research Career Development (K23) award supports Dr. Siddika Mulchan's five-year research program investigating provider-focused interventions to improve health outcomes...

Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Illinois a $755,853 Project Grant effective September 15, 2025, through June 30, 2030, under the Cardiovascular Diseases Research program (CFDA 93.837). This award funds research investigating sodium-glucose cotransporter-2 inhibitors (SGLT2i) as a therapeutic intervention for sickle cell disease (SCD)-related chronic kidney disease (CKD). The research will leverage preliminary data...

Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of North Carolina at Chapel Hill a $1,654,517 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) effective May 1, 2025, with completion targeted for January 31, 2030. The research investigates the role of endothelin-1 (ET-1) in renal iron accumulation associated with sickle cell disease (SCD) nephropathy. The project will deliver scientific findings on...

Federal Grant Award Summary Vanderbilt University Medical Center received a $232,836 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective December 1, 2025 through November 30, 2027. This award supports quantitative neuroimaging research to develop biomarkers of ischemic risk in adults with sickle cell disease (SCD). The research employs non-invasive advanced imaging methods, including arterial spin...

This $403,750 Project Grant from the National Eye Institute of the Department of Health and Human Services will fund research into the regulation of retinal microvascular stiffness by the matricellular protein CCN1 and its implications for ischemic retinopathy. The awardee, the Research Foundation for the State University of New York on behalf of SUNY Downstate Health Sciences University, will investigate the effects of CCN1 on the mechanical properties of retinal microvascular endothelial cells...

Grant Award Summary Emory University received a $110,635 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on September 12, 2025, with completion targeted for August 31, 2027. The research investigates the role of blood rheology and transfusion practices in microvascular thrombosis during sepsis, addressing critical gaps in understanding the pathophysiology underlying organ failure and high mortality...