Project Grant R43HL126285

Rattan Life Science Inc. received a $275,000 Project Grant award from the National Science Foundation under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a platform for generating induced pluripotent stem cell-derived naïve CD4+ and CD8+ T cells with fidelity, reproducibility and scalability. The platform employs proprietary induced thymic epithelial cells to provide biologically relevant thymic positive selection signals during T cell differentiation,...

This Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program (CFDA 47.084) provides $275,000 to Dcan Biosciences LLC to develop an advanced microfluidic system for cancer diagnosis and monitoring. The system aims to isolate and assess circulating tumor cells (CTCs) and CTC clusters (CTCCs) from patient blood samples to enable highly sensitive and accurate liquid biopsies. Key objectives include designing a hybrid microfluidic device for...

The National Science Foundation awarded Ireprogram, LLC a $256,000 Project Grant under the Small Business Technology Transfer (STTR) program. The grant supports an STTR Phase I project to develop autologous hematopoietic stem cell production techniques to treat graft-versus-host disease. The STTR program seeks small business innovation research and development through public-private partnerships. This award will allow Ireprogram to research stem cell therapies with the goal of ending this...

This $256,000 National Science Foundation project grant supports the development of an automated chest tube to prevent clotting. Circulatech LLC will design and prototype a novel chest tube that proactively manages fluid flow within the catheter lumen to flush and drain the tube, reducing blood clot formation. Through a process called "dilutional coagulopathy," the tube will use sterile saline or anticoagulants to reduce thrombosis in the drainage space rather than relying on...

The National Science Foundation awarded Cytorecovery Inc. a $255,986 Small Business Technology Transfer Phase I Project Grant under the Engineering program (CFDA 47.041) on March 15, 2021. The grant funded the development of on-chip integration of sample preparation and monitoring capabilities with dielectrophoretic cell isolation techniques. The Engineering program seeks to improve quality of life and economic strength by fostering innovation and excellence in engineering research. This award...

This $255,991 National Science Foundation project grant supports the development of an automated system for rapid analysis of biopsy samples by Amcyt, Inc. The system aims to increase the efficiency and accessibility of fine needle aspiration biopsy procedures through three automated processes: sample smearing, staining, and image capture. This addresses a critical need to improve biopsy analytics and potentially eliminate up to 20% of failed procedures due to sampling errors. By automating...

Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Columbia University a $729,703 Project Grant on July 10, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop and optimize cell sorting technology for stem cell therapy applications. The research focuses on developing "nanovials," an innovative platform designed to isolate and enrich mesenchymal stem cells (MSCs) based on their extracellular vesicle (EV)...

This $500,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), will support research to develop an end-to-end continuous manufacturing process for cell therapies using robotics and microfluidic technologies. The Georgia Tech Research Corporation will receive funding to create a more integrated workflow based on microfluidic device-enabled genetic engineering, cell expansion, and...

This $125,805 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop new cell sorting technologies that can identify and separate cells based on changes in the activity of naturally occurring light-emitting molecules like NAD(P)H. The goal is to enable label-free, rapid identification and purification of cell populations, with a focus on stem cells and their functional subsets. The research will create a single cell deposition module to...

Celldrop Inc. received a $256,000 Small Business Technology Transfer (STTR) Phase I Project Grant award from the National Science Foundation on May 1, 2021 to develop allogeneic stem cell delivery for efficacy-enhanced equine biotherapeutics. The award supports research and development activities at Celldrop's Laramie, Wyoming facility through November 30, 2022. The project aims to advance Celldrop's stem cell delivery platform technology under the NSF's Technology, Innovation, and...