Project Grant R43HL118792

Percassist Inc. received a $663,129 Project Grant award from the National Heart Lung and Blood Institute of the Department of Health and Human Services. The award was made under the Cardiovascular Diseases Research program (CFDA 93.837), which supports heart and vascular research. The grant funds the development of a percutaneous ventricular assist device for chronic heart failure patients. Specifically, Percassist will design and test a balloon catheter implant that can be delivered minimally...

This Project Grant award of $606,609 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) is focused on developing a novel photostimulation system for cardiac resynchronization therapy. The key objectives are to design, fabricate, and evaluate a range of porosity-based silicon heterojunction devices tailored for optical modulation of cardiac tissues. The...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $1,024,635 to Corvion, Inc. to develop a Totally-Implanted Left Ventricular Assist Device (TI-LVAD). The TI-LVAD aims to reduce complications and improve quality of life for patients with heart failure compared to current LVAD technologies, which require a percutaneous driveline and external power supply. The key innovation is a hybrid...

This Project Grant award of $786,188, issued by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to develop a novel, biodegradable gene therapy delivery system to prevent the failure of prosthetic bypass grafts. The research team at Beth Israel Deaconess Medical Center, Inc. (Bidmc) aims to optimize their gene therapy platform by enhancing the hydrogel's degradation rate, tissue adherence, and targeted...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), will fund the development and testing of a new extracorporeal membrane oxygenation (ECMO) pump designed for efficient low-flow operation in pediatric and neonatal patients. The goal is to create an ECMO pump capable of operating at flow rates between 50-500 cc/min, which is an order of magnitude lower than current pump designs, in...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $437,461 to 3DT Holdings, LLC, a minority-owned biomedical engineering company, to develop a novel stabilization catheter for His pacing lead implants. The goal is to improve the success rate and accuracy of His bundle pacing, an emerging alternative to cardiac resynchronization therapy (CRT) for heart failure patients. The project aims...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop a drug-eluting chest tube for local pain management after cardiothoracic surgeries. The $275,752 grant, awarded to Medical Elution Devices LLC, seeks to complete GMP/GLP studies on drug release kinetics, stability, and manufacturing repeatability, as well as evaluate the mechanical stability and clinical usability of the device...

This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop a novel hydrogel-based system for delivering gene therapy to the heart. The primary awardee, Emory University, will engineer a hydrolysis-cleavable polyethylene glycol (PEG) hydrogel to target the epicardium and optimize cardiac transduction of gene therapy vectors. The total funding amount is $635,300.00, with a...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $454,049 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to Drexel University. The grant supports the development of an innovative central venous catheter device that can provide continuous and accurate measurements of cardiac output in critically ill patients. Key technical innovations include: 1) Using a Doppler ultrasound...

This $580,863 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports the development of silicon nanowire-engineered human cardiac organoids for heart repair. The key products or services to be delivered include: Optimizing the surface roughness of electrically conductive silicon nanowires (e-SiNWs) to improve their electrical interactions with human pluripotent stem cell-derived cardiomyocytes...