Project Grant R43HD115494

This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) is funding the development and validation of a non-invasive microbiome-based diagnostic tool for the early detection of gestational diabetes mellitus (GDM). The awardee, Brooklyn Innoseq Inc. (doing business as Mamome), will enroll 250 pregnant women to collect stool samples in the first trimester and at the GDM diagnosis window. This will enable metagenomic analysis to identify microbiome biomarkers associated with GDM risk. The project aims to develop a predictive machine learning model to create a screening test that can detect GDM in the first trimester, prior to the current standard oral glucose tolerance test. The total award amount is $296,351, with a performance period from July 22, 2024 to June 30, 2025.