Project Grant R43GM161143
- This Phase 1 SBIR Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), provides $306,872 to Peptiforge, Inc. to establish a platform for rapid development of therapeutic protein binders. The grant aims to synthesize test libraries of therapeutic protein scaffolds and evaluate the feasibility of Peptiforge's platform for accelerating the discovery of protein binders that can target...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $124,767 to The Regents of the University of California, San Francisco (UCSF) to develop and test a pipeline for the de novo design of protein "enfolds" that can conditionally release cell-penetrating peptides (CPPs) and antimicrobial peptides (AMPs). The goal is to enhance the tissue specificity and stability of...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $202,274 to develop an easy-to-use computer program for predicting the structure and degrading efficiency of proteolysis targeting chimeras (PROTACs). PROTACs are heterobifunctional molecules that induce the degradation of target proteins by recruiting them to E3 ubiquitin ligases. The awarded project aims to implement a...
- This Project Grant award of $384,896.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop novel peptide-based biomaterials that can directly modulate cell and tissue responses. The goal is to create advanced biomodulatory materials, such as self-adjuvanting vaccines, anti-inflammatory therapeutics, cell-targeted cancer therapies, and bone regenerative products, to address challenges in...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $221,448 project grant to the Massachusetts Institute of Technology (MIT) on May 15, 2025. The grant supports the development of peptide catalysts for stereo- and site-selective carbon-carbon bond formation using automated fast-flow peptide synthesis and machine learning. The research aims to leverage MIT's expertise in areas such as molecular...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA 93.859 Biomedical Research and Research Training, provides $585,000.00 to the University of Texas at Dallas to pursue innovative strategies and platforms for (a) discovering 'natural product'-like macrocyclic peptides as modulators of biomolecular interactions, and (b) developing biocatalytic strategies for asymmetric synthesis via 'new-to-nature' chemistries. The project builds upon prior...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $781,502 to Chemia Biosciences, Inc. to develop NATDISCOVERY, a novel computational platform for identifying new non-ribosomal peptide natural product molecules. The overarching goal is to integrate genome mining with computational metabolomics to systematically discover novel natural product small molecules from...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop new chemical strategies for controlling the conformation of bioactive peptides and proteins. The $385,671 award, effective from September 1, 2025 to August 31, 2030, aims to synthesize and evaluate novel amino acid analogs that can influence the secondary structures of peptides and proteins, with the goal...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $431,800 to The University of Texas Southwestern Medical Center (UT Southwestern) to develop enhanced pipelines for proteome-wide protein-protein interaction (PPI) screening in humans. The project aims to leverage breakthroughs in protein structure prediction using deep learning and extensive genomic data to...
- The National Institute of General Medical Sciences (NIGMS) awarded a $306,872 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Fluid Discovery, Inc., a San Francisco-based biotechnology company, to develop a "Universal Platform for Ultrahigh-Throughput Biocatalyst Evolution with Micro-Mass Spectrometry." The award supports the development of a commercial prototype for Fluid Discovery's novel screening platform, which combines scalable hardware,...
This Project Grant award of $404,032 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a machine learning-powered platform for the discovery of peptide ligands for peptide-drug conjugates (PDCs). The key objective is to create a next-generation peptide discovery system capable of identifying PDC leads within 3 months. The platform will utilize a peptide array designed for enhanced protease stability, with sequences selected using unsupervised machine learning approaches to achieve high diversity and uniform coverage of the design space. The platform will also employ advanced assays to accurately measure target and off-target binding while estimating kinetic parameters. During the Phase I effort, the project aims to demonstrate that the designed peptide arrays can effectively identify stable and specific binders to the PDC target Nectin-4. The award will fund this research from September 1, 2025 to August 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $404.0k | 8/27/25 |