Fully autonomous robotic wet lab for stem cell culture media optimization

Ended Project Grant Awarded Last action

Award ID
R43GM159517
Recipient
Awarding agency
Obligated
$350,000

Award facts

Assistance listing
93.859 Biomedical Research and Research Training
Completion date
Place of performance
Minnesota, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Hematopoietic stem cells (hscs) are perhaps the most important and immediately actionable cells for cell rejuvenation therapies, but the difficulty of growing them in the lab limits their potential. To address this problem, we are using a fully autonomous, ML-driven wet lab to optimize HSC culture media. Our system, which we refer to as a "machine biologist", has two major components: the "body", consisting of a robotic wet lab capable of performing HSC culture experiments, and the "mind", consisting of an machine learned (ML) computer vision model for analyzing our microscopy results and a bayesian optimizer to perform experimental design. This combination will allow our system to operate fully autonomously, and proceed orders-of-magnitude faster than is possible in a conventional biology lab. Our work has the potential for transformative impact on both the way cell biology research is conducted as well as HSC-based cell therapies.

Transactions

Action Obligated Date
Amendment $0
Original award $350,000

Quick answers

Who received award R43GM159517?

R43GM159517 was awarded to Dragonase LLC by National Institute of General Medical Sciences (National Institutes of Health) on June 1, 2025.

How much is award R43GM159517 worth?

$350,000 has been obligated on R43GM159517.

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