Project Grant R43GM156150
Award Date
9/1/24
Completion Date
8/31/25
Dollars Obligated
$300K
Federal Agency
National Institute of General Medical Sciences
Awardee
Lifesensors Inc. (ECPPNPPB5U31)
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
Similar Awards
The National Institute of General Medical Sciences (NIGMS) awarded a $440,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Sloan-Kettering Institute for Cancer Research in New York. The 5-year grant, awarded on February 3, 2025, supports advanced research to decode the ubiquitin and autophagy signaling networks, which are essential cellular processes involved in proteome homeostasis. The research program combines expertise in quantitative mass spectrometry,...
The National Institute of General Medical Sciences (NIGMS) awarded a $645,712 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Trustees of Tufts College in Medford, MA. The grant supports the development of new chemical biology tools to study protein post-translational modifications, specifically glycation and ubiquitination, in living cells. The research aims to uncover how these modifications are integrated into cellular signaling networks and...
The National Institute of General Medical Sciences (NIGMS) has awarded a $365,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Montclair State University. The grant will fund research to study the structural mechanism of spontaneous ubiquitin cargo clustering on the cell plasma membrane. The principal investigator will use fluorescence microscopy and atomic force microscopy techniques to identify the structural organization of ubiquitin cargo...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $528,129 to the University of Connecticut Health Center to conduct research on the ubiquitin-proteasome pathway and its role in human disease. The key objectives of this 5-year research program are to: Structurally and functionally characterize critical ubiquitinating and de-ubiquitinating enzymes implicated in human...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $202,274 to develop an easy-to-use computer program for predicting the structure and degrading efficiency of proteolysis targeting chimeras (PROTACs). PROTACs are heterobifunctional molecules that induce the degradation of target proteins by recruiting them to E3 ubiquitin ligases. The awarded project aims to implement a...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) is funding the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology by Biosensing Instrument Inc. The SFNOA system aims to enable high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The $349,566 award, effective from April 2, 2025 to March 31, 2026,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $295,561 to Biosensing Instrument Inc. to develop a commercial prototype of their Plasmonic Scattering Microscopy (PSM) technology. The PSM system aims to enable high-throughput, label-free quantification of membrane protein binding kinetics on single cells in their native cellular microenvironment. This represents a...
This $380,540 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to decipher new principles of rapid proteostatic control and develop spatiotemporal lysosomal tools. The key research activities include: 1) defining novel protein substrates and motifs required for lysosomal delivery, 2) determining the functional impact of methyl-driven lysosomal proteolysis on...
This $350,000 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) to Black Hills State University in Spearfish, South Dakota. The grant supports the development of genetically encoded sensors to quantify unconjugated NEDD8, a post-translational modifier that regulates cullin-ring E3 ligases, which are being explored as drug targets for solid-tumor cancers. The research aims to...
This Project Grant award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships program) provides $275,000 to Ubiquitx Inc., a New York-based small business, to develop a programmable, modular therapeutic platform for the direct modification of proteins of interest (POIs) using artificial intelligence, protein engineering, and mRNA therapeutics. The goal is to expand the applications of the company's Chimeric Ligands for Induced Proximity (CLIPS)...