This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $295,561 to Biosensing Instrument Inc. to develop a commercial prototype of their Plasmonic Scattering Microscopy (PSM) technology. The PSM system aims to enable high-throughput, label-free quantification of membrane protein binding kinetics on single cells in their native cellular microenvironment. This represents a...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $304,196 to Laser Bioanalytics LLC for the development of a prototype instrument and techniques for photochemical patterning of lipids in tissue sections. The goal is to enable improved mass spectrometry structural analysis and imaging of lipids, which are important cellular components relevant to disease diagnosis...
The National Institute of General Medical Sciences (NIGMS) awarded a $267,323 Project Grant (CFDA 93.859) to Uforce Biotechnology, LLC to develop a quantum sensing device to accelerate the drug development process and increase its success rate. The proposed device, based on the Super-Resolution Force Spectroscopy (SURFS) technique, aims to provide unprecedented data on the binding strengths between drug molecules and their biomolecular targets. Key objectives include integrating a commercial...
This $295,308 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will support the development and validation of a novel class of scanning probe microscopy (SPM) probes for rapid identification of infectious disease agents. The awardee, Actoprobe LLC, aims to dramatically improve the sensitivity and spatial resolution of scanning...
The National Institute of General Medical Sciences (NIGMS) awarded a $338,843 project grant under CFDA 93.859 (Biomedical Research and Research Training program) to Nanoengineering Corporation (NEC) to develop an electrospray differential mobility analysis (ES-DMA) soft landing system. The goal is to overcome limitations of existing mass spectrometry-based protein separation and deposition techniques for cryogenic electron microscopy (cryo-EM) structural analysis. The project aims to demonstrate...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program provides $306,860 to Mixedlcmedia LLC, a small disadvantaged business, to develop and evaluate a prototype ultra-low flow liquid chromatography platform based on their proprietary porous layer open-tubular (PLOT) and monolithic nanocolumn technologies. The goal is to create a commercialization-ready LC system that enables deep proteomic...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $330,076 in funding to Trestle Optics LLC, a small disadvantaged business located in Irvine, California. The funding supports the development of a novel photothermal microscopy platform integrated with spatial light interference imaging. This advanced optical system will enable non-destructive profiling and mapping...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $349,566 to Biosensing Instrument Inc. to develop a Spotting-Free Nano-Oscillator Array (SFNOA) technology for high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The SFNOA technology integrates several innovative techniques, including virion-displayed transmembrane...
This federal Project Grant award in the amount of $271,495.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development and evaluation of a time-of-flight (TOF) mass spectrometer system with matrix-assisted laser desorption/ionization (MALDI) for fast analysis of antibodies and related macromolecular immune complexes. The goal is to utilize a novel high-temperature superconducting...
This federal Project Grant award, valued at $417,400.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The project aims to develop and advance mass spectrometry imaging (MSI) tools that will enable more accurate and comprehensive chemical characterization of the glycome (the complete repertoire of cell carbohydrates) at the tissue functional unit and cellular resolution. The research will...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program provides funding of $258,586 to MSTM LLC to develop an advanced surface sampling and ionization technology for remote detection of molecular compositions. The goal is to demonstrate the feasibility and proof-of-concept of a "Surface Reader" device that can directly sample surfaces using a liquid meniscus or indirectly via laser ablation, and interface with mass spectrometry systems to differentiate diseased vs. normal tissue through computer-aided mass-to-charge fingerprint recognition. This 12-month Phase I project is expected to lay the groundwork for a future Phase II effort to implement an FDA-approved CO2 laser and machine learning algorithms into a commercial product requiring minimal user expertise. The award supports MSTM's efforts to advance this disruptive technology with the potential for widespread applications in healthcare, including early-stage detection of infectious diseases, hazardous materials, and cancer.