The National Institute of General Medical Sciences (NIGMS) awarded a $218,622 Project Grant to Vitan-Biotech LLC on September 22, 2023 under the Biomedical Research and Research Training program (CFDA 93.859). The grant will fund the development of an integrated pipeline to rapidly discover and characterize selective, high-affinity nanobodies against defined G protein-coupled receptors (GPCRs) that are important for neurological disorders like schizophrenia, pain, Parkinson's, Alzheimer's, and...
The National Institute of General Medical Sciences (NIGMS) awarded a $324,239 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Ora Biomedical, Inc., a biotechnology company in Seattle, WA. The purpose of this Phase I Small Business Innovation Research (SBIR) grant is to develop "ELEGANTRY", a software and hardware infrastructure to improve rigor and reproducibility in invertebrate research using the model organism Caenorhabditis elegans (C....
The National Institute of General Medical Sciences (NIGMS) awarded a $333,048 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. in Houston, TX. The goal of this 1-year project is to develop a versatile 2-photon microscopy platform, dubbed 2P-SPOTLIGHT, to isolate individual cells from 3D tissue samples and 3D cell cultures based on their spatial and temporal properties. This will enable researchers to conduct downstream multi-omics...
This Project Grant award of $350,000.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop an artificial intelligence-based platform for optimizing peptide-based drug candidates. The key products or services to be delivered include: Methods for encoding non-canonical amino acids and cyclic peptides to enable high-performance machine learning on commercial peptide sequence, activity, stability, and...
The National Institute of General Medical Sciences (NIGMS) awarded a $905,853 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Molecular Instruments, Inc. to develop innovative signal amplification technologies for automated, ultrasensitive, and multiplex imaging of RNA and proteins in biological samples. The 2-year project aims to engineer novel chromogenic and fluorescent signal amplification cascades based on hybridization chain reaction (HCR) to enable 4-plex RNA in...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) federal grant program, awarded Dragonase LLC a $350,000 Project Grant (Award ID R43GM159517) to develop a fully autonomous robotic wet lab for optimizing hematopoietic stem cell (HSC) culture media. The project aims to use machine learning-driven computer vision and Bayesian optimization to automate HSC culture experiments, enabling faster and more efficient research...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $781,502 to Chemia Biosciences, Inc., a Pittsburgh-based small disadvantaged business, to develop NATDISCOVERY - efficient and accurate computational methods for identifying novel non-ribosomal peptides from complex mass spectral datasets. The overarching goal is to create a novel platform for discovering natural product...
The National Institute of General Medical Sciences (NIGMS) awarded a $371,427 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) program to Carnegie Mellon University (CMU) to develop novel high-throughput machine learning approaches for studying cell population-wide differences in subcellular object morphology, conformations, and organization using cryo-electron tomography (cryo-ET) data. The 5-year project aims to improve the data efficiency of existing deep...
The National Institute of General Medical Sciences (NIGMS) awarded a $349,816 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Narwhal Bio, Inc. in San Diego, CA. The grant supports the development of a prototype instrument, software, and consumable for non-invasive live-cell identification, tagging, and downstream characterization. This novel platform aims to enable researchers to study clinically relevant cell-cell interactions that drive diseases like...
This Project Grant award, with a total funding amount of $349,566.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training federal grant program (CFDA 93.859). The award, granted on April 2, 2025, supports the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology by Biosensing Instrument Inc., a for-profit company based in Tempe, Arizona. The SFNOA technology aims to address key challenges in the...