Project Grant R43GM150301
Award Date
9/1/23
Completion Date
8/31/24
Dollars Obligated
$275K
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
Similar Awards
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $781,502 to Chemia Biosciences, Inc., a Pittsburgh-based small disadvantaged business, to develop NATDISCOVERY - efficient and accurate computational methods for identifying novel non-ribosomal peptides from complex mass spectral datasets. The overarching goal is to create a novel platform for discovering natural product...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program provides $308,925 to Chemia Biosciences, Inc. to develop computational technologies for discovering novel fungal natural products with potential antimicrobial and therapeutic applications. The primary goal is to create software that can predict the molecular structures of natural products encoded in fungal genomes, leveraging high-throughput...
This Project Grant award from the National Center for Advancing Translational Sciences (CFDA 93.350) provides $317,029 in funding to Chemia Biosciences, Inc., a small disadvantaged business, to develop advanced computational methods and software tools for discovering novel antimicrobial natural products. The project aims to leverage high-throughput mass spectrometry and genome mining techniques to identify new polysaccharides and aminoglycosides, a class of antibiotics, to address the growing...
This Project Grant award, identified as R35GM152006, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) federal grant program. The award, valued at $752,456, supports the University of Pittsburgh in developing innovative, user-friendly computational technologies to (1) identify new bioactive small molecules and (2) improve their pharmacological properties. This work aims to accelerate the drug discovery...
This federal Project Grant award, identified as R35GM152049, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program. The $492,000 award supports a 5-year research project conducted by The Trustees of Princeton University that aims to expand the chemical space of microbial and microbiome natural products. Key objectives include elucidating cryptic metabolites in diverse microbial genera, especially...
This Project Grant award of $146,816 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to develop biocatalytic synthesis methods for N-N and C-N heterobiaryl atropisomers. The principal investigator will employ bioinformatic techniques to create a library of flavin-dependent aromatic hydroxylase (FDAH) enzymes and study their reactivity profiles to identify features that enable...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is funding research at the Massachusetts Institute of Technology (MIT) to study the biogeography and combinatorial effects of microbial and plant-derived redox-active small molecules on microbial growth and community dynamics. The $393,718 award, effective from April 2025 through February 2030, will support a two-pronged approach....
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program provides $450,313 to The Johns Hopkins University from June 1, 2025 to May 31, 2030. The purpose of this grant is to investigate the molecular mechanisms and dynamic domain interactions that govern the function of nonribosomal peptide synthetases (NRPSs), which are complex, multi-domain enzymes that synthesize natural products with...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is supporting research to identify and characterize novel dehydrated nonribosomal peptides from Streptomyces bacteria. The $300,892 award to the University of North Carolina at Chapel Hill aims to discover previously unknown dehydrated nonribosomal peptides, determine their biosynthetic pathways, and assess their potential...
The National Institute of General Medical Sciences (NIGMS) awarded a $422,931 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Colorado-Denver on July 1, 2025. The goal of this 5-year research project is to characterize how specialized microbial metabolites mediate interactions within the human microbiome, and how these metabolite-driven community dynamics influence susceptibility to antimicrobial treatments. The research will integrate cheminformatics...