Toxicological screening in a single animal format
Ended Project Grant Awarded Last action
- Award ID
- R43ES034324
- Recipient
-
Theramix LLC UEI NPYUSJHF5KS9
- Awarding agency
-
National Institute of Environmental Health Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $519,226
Award facts
- Assistance listing
- 93.113 Environmental Health
- Completion date
- Originally
- Place of performance
- California, USA
Award details come from USAspending.gov.
Description
- Abstract
- Toxicity testing with animals has limitations with regards to cost, time, reliability, and animal welfare. We propose to develop a novel toxicological screening approach in a single animal format for quickly assessing the safety of chemicals with reduction of animal use and improved animal welfare. We will develop a new testing procedure with which we could perform tests in only one animal to obtain information on the effective doses, impacted tissues, and organs, and toxicodynamics of toxicants, which usually need experimenting on hundreds of animals, months to years efforts, and enormous biochemical and pathological analyses in the traditional toxicological study. The breakthrough technique is a reporter system for real-time mapping cellular damage caused by chemical substances in the whole body. IT can detect the toxic effects of substances as early as cellular damage occurs in the body. Whereas in traditional animal testing, adverse effects only become detectable/measurable in animals exhibiting significant degrees of adverse health effects after receiving high doses of test chemicals. Instead of taking the animal body as a "black box" in the traditional testing, our new technique enables real-time monitoring responses to a chemical by making the animal body transparent for directly observing adverse effects at the cellular level.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $259,613 | |
| Original award | $259,613 |
Quick answers
Who received award R43ES034324?
R43ES034324 was awarded to Theramix LLC by National Institute of Environmental Health Sciences (National Institutes of Health) on September 23, 2022.
How much is award R43ES034324 worth?
$519,226 has been obligated on R43ES034324.
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