The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $518,661 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Vanderbilt University Medical Center (VUMC) on August 16, 2024. The grant, titled "Beyond Urea Kinetics: Balancing Tradeoffs in Dialyzer Design for the Next 50 Years," aims to improve dialysis treatment for the 548,000 Americans suffering from kidney failure. The project will...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $591,844 to Allvivo Vascular, Inc. to develop a catheter end cap with an antimicrobial luminal insert. The goal is to reduce the risk of bloodstream infections in hemodialysis patients, which are a leading cause of hospitalization and death in this population. The project aims...
This Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847) program. The $324,836 award to Flowpoint Medical Inc. aims to develop an implantable device to improve vascular access for hemodialysis patients. The device features a 3D-printed titanium shell that guides the needle to the correct insertion point, while a titanium-nitride coated valve stops...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Fibrotherapeutics Inc. a $675,480 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to develop a novel therapeutic compound for treating chronic kidney disease. The funding supports preclinical research to evaluate the efficacy, safety, and therapeutic index of a modified, water-soluble version of the caveolin-1 scaffolding domain (CSD) peptide, which has shown promise in...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $312,088 to Sojourn Medtech LLC to develop the CANSIM simulator. The CANSIM is a smart, personalized, and dialysis-specific training device to teach critical cannulation skills to dialysis nurses and patient care technicians. The key features include: 1) dialysis-specific design, 2) realistic and low-maintenance...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $499,890 Project Grant (CFDA 93.847) to Pavaj Vascular Corporation to develop a novel therapy to prevent arteriovenous fistula (AVF) venous stenosis, a leading cause of failure in hemodialysis patients with end-stage kidney disease. The project aims to evaluate the stability and biocompatibility of nanoparticles composed of poly(lactic-co-glycolic acid) (PLGA) encapsulated with the active form of vitamin D3,...
The U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $647,486 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to Inlighta Biosciences L.L.C., a woman-owned small business located in Marietta, Georgia. The grant supports the design and generation of calcium-sensing receptor (CaSR) targeted theragnostic agents, including novel CaSR agonists and antagonists. The project also involves developing CaSR-targeted PET...
This Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $548,830 to Nephsmart LLC to develop and test a point-of-care device to predict the future development of severe acute kidney injury (AKI). The award period runs from August 1, 2024 to July 31, 2025. The device leverages the discovery that extensive cleavage of a specific protein...
This Project Grant award of $3,740,270 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports the development of a platform for extended kidney preservation via subnormothermic perfusion. The award aims to optimize the engineering of the platform, evaluate the impact of warm ischemic injury and duration of preservation on kidney graft injury, and compare the function...
This federal Project Grant award of $550,000 from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development of a remote monitoring system to reduce infections among patients undergoing peritoneal dialysis (PD). The Johns Hopkins University, the grant recipient, will: (1) use simulation models to optimize the optical and flow chamber design parameters for high-resolution and high-throughput characterization of flowing...