Project Grant R43DE034316
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $491,193 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of California, San Diego (UCSD) for the project "Engineering Mucin Analogues to Benefit the Mouth Environment." The project aims to create advanced mucin substitutes that closely emulate the physiological functions of natural salivary mucins, in order to develop enhanced artificial saliva...
- The U.S. National Institute of Dental and Craniofacial Research (NIDCR) awarded a $298,942 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to Deltamed LLC, a startup company in Kansas City, Missouri. The grant supports the development of a nanosponge drug delivery system that will encapsulate and release small molecule MK2 inhibitors, such as apatinib and MMI-0100, to prevent and treat radiation-induced oral cavity and salivary fibrosis in head and neck...
- This Project Grant award of $429,000 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research at the University of South Alabama to investigate the use of phosphodiesterase 4 (PDE4) inhibitors as a novel therapeutic approach for treating dry mouth (xerostomia) associated with Sjögren's syndrome. The key objectives are to evaluate how PDE4 inhibition can: 1) potentiate both parasympathetic and...
- This federal Project Grant award of $409,960.00, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop a human salivary gland-on-a-chip model to study dry mouth (hypofunction) caused by radiotherapy. The project will 1) create a normal salivary gland organ-on-a-chip model composed of epithelial cells, endothelial cells, and macrophages, and validate its secretory functions, and 2)...
- The National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health (NIH), awarded a $3,118,158 Project Grant to Hydronovo, Inc. under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program. The purpose of the grant is to develop Hydronovo's "Ceviginate (CVGN8)" - an injectable neuromimetic hydrogel that aims to regenerate radiation-damaged salivary glands by restoring the function of salivary stem cells. Hydronovo has...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $309,038 Project Grant to Virtici LLC, a for-profit biomedical research and development company based in Seattle, Washington. The purpose of this grant is to develop a novel inhibitor targeting the "red complex" bacteria P. gingivalis, T. forsythia, and T. denticola, which are considered the causative agents of...
- This $643,574 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports research to determine the therapeutic potential and mechanisms of induced pluripotent stem cell-derived mesenchymal stem/stromal cell (iPSC-MSC) extracellular vesicles in treating dry mouth caused by Sjögren's syndrome or radiation therapy. The project aims to investigate the immunosuppressive and...
- The U.S. National Institute of Dental and Craniofacial Research (NIDCR) awarded a $226,500 Project Grant on May 1, 2025 to The Medical University of South Carolina under the Oral Diseases and Disorders Research (CFDA 93.121) program. The goal of this 2-year project is to define how oral pathogens affect aging-associated immune responses and whether inhibition of the CD38 signaling pathway can attenuate inflammatory bone loss and alleviate aging-related immune responses induced by oral...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $297,711 Project Grant to Periomics Care LLC under the Oral Diseases and Disorders Research program (CFDA 93.121). The objective of this Phase I study is to develop and evaluate zinc tetraammine difluoride (ZAF) as a non-invasive, aesthetic, and cost-effective alternative to traditional dental caries management strategies. The project aims to determine the mineral loading efficacy of ZAF agents in human dentin to enable...
- This $164,255 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop innovative methacrylate-based dental materials to inhibit microbial biofilm formation and prevent secondary caries. The key objectives are to: (1) synthesize a derivative of the 2-aminoimidazole family of small molecules and generate a new methacrylate-based antimicrobial agent containing this compound,...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $406,496 Project Grant under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) to Antixero, a for-profit limited liability company located in Raleigh, North Carolina. The funding supports the development of an all-in-one hyaluronic acid-based oral rinse solution that provides extended relief, for approximately 24 hours, for cancer-associated xerostomia (chronic dry mouth). This work builds on Antixero's prior development of lubricant technologies for dry eye disease, adapting the innovative approach to address the significant unmet medical need for longer-lasting dry mouth treatments. The project has a performance period from August 25, 2025 to August 24, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $406.5k | 8/25/25 |