Project Grant R43DE023461

The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $294,632 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to Greenmark Biomedical Inc. in East Lansing, Michigan. The project aims to develop an intraoral imaging system that uses targeted nanoparticle-enhanced fluorescent technology and artificial intelligence (AI) algorithms to improve early detection and monitoring of dental caries (tooth decay). Specifically, the project involves...

The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,414,853 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Innotech Precision Medicine, Inc., a woman-owned small business, to develop RECOGNIZE-OPSCC. This saliva-based, point-of-care diagnostic test aims to provide rapid, non-invasive, and accurate detection of oropharyngeal squamous cell carcinoma (OPSCC). The project integrates an AI-enabled, ultraportable device with an...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $341,970.00 to Oralmr LLC to test the feasibility of using a specialized pulse sequence and intraoral coil to detect the dentinoenamel junction (DEJ) in teeth at a lower field strength (0.7T) with greater inhomogeneity than conventional MRI systems. The goal is to develop a cost-effective, dental-dedicated MRI system that...

This $550,296 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop a multimodal imaging diagnostic platform to improve risk assessment of precancerous oral lesions. The key products and services to be delivered under this grant include: Development of machine learning and deep learning models using Fourier transform infrared (FTIR) imaging techniques for risk...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $294,505 to support the development and commercialization of a targeted fluorescence dye for intraoperative imaging and precision surgical treatment of head and neck cancer (HNC). The goal is to create a small peptide-based fluorescent probe that can specifically stain HNC tumors to assist surgeons in identifying tumors...

The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,178,476 Project Grant under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) to Oraliva, Inc., a technology company in Durham, North Carolina. The purpose of this 2-year project, with a completion date of March 31, 2027, is to develop an AI-linked cytomics-on-a-chip technology to enable near real-time identification and management of oral lichenoid lesions in primary care settings. This...

The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $421,625 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Texas A&M Engineering Experiment Station (Tees) to develop advanced tumor microenvironment chips (TME-chips) that incorporate functional blood and lymphatic capillary networks. The objective is to create innovative in-vitro systems that can accurately model oral squamous cell carcinoma (OSCC) tumor microenvironments,...

The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $870,334 Project Grant to The Research Foundation For The State University Of New York (RF SUNY) for the project "DEVELOPMENT OF AN EARLY TOOTH ORGANOID VIA HUMAN INDUCED PLURIPOTENT STEM CELLS". The goal of this 2-year project is to develop an in vitro system using human induced pluripotent stem cells (iPSCs) to better...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $623,622 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to the University of Arizona to develop a novel Probe-Based Light Sheet Microscopy (PLSM) device for improved screening of anal cancer. The 4-year project aims to evaluate the clinical utility of PLSM for in vivo imaging of the anal mucosa to detect precancerous lesions, as...

This National Science Foundation Project Grant of $255,757 awarded on August 15, 2022 will fund the development of an ultrasound-based point-of-care periodontal imaging device under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084). Stylosonic LLC will develop an integrated device for acoustic imaging of the entire mouth that automatically processes imaging data to assist dentists in assessing gingival health and periodontitis. Key objectives include miniaturizing imaging...