Project Grant R01EB036693

Award Date 1/13/25
Completion Date 12/31/28
Dollars Obligated $273K
Federal Grant Program
93.286
Assistance Type
Project Grant
Place of Performance
Tucson, AZ 85721, USA
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This $272,835 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) program, aims to develop a new Probe-Based Light Sheet Microscopy (PLSM) device and evaluate its clinical utility for in vivo imaging of the anal mucosa during cancer screening. The University of Arizona, as the prime awardee, will collaborate with researchers from Memorial Sloan Kettering and Stanford University to achieve the following goals over the 4-year award period:

  1. Develop the PLSM device to provide high-resolution, non-invasive imaging of the anal canal during cancer screening, potentially improving diagnostic accuracy and reducing unnecessary biopsies.
  2. Conduct an in vivo human imaging study to evaluate the clinical utility of the PLSM device for detecting high-grade precancerous lesions.
  3. Develop automated image analysis algorithms to assist clinicians in interpreting the PLSM images.

The overarching objective is to aid early detection of anal cancer, a condition with rapidly increasing incidence and mortality, through this innovative optical imaging approach.

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