Development of a highly specific and sensitive HSV-1 and HSV-2 diagnostic test
Ended Project Grant Awarded Last action
- Award ID
- R43AI176913
- Recipient
-
Rational Vaccines Inc. UEI PKJWJVTMUS63
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $291,480
Award facts
- Assistance listing
- 93.855 Allergy and Infectious Diseases Research
- Completion date
- Originally
- Place of performance
- Massachusetts, USA
Award details come from USAspending.gov.
Description
- Abstract
- Infections with herpes simplex virus type-1 (HSV-1) or herpes simplex virus type-2 (HSV- 2), the causative agents of genital herpes, are highly prevalent worldwide. The world health organization (who) estimates that more than 3.7 billion people under the age of 50 are infected with HSV-1, and approximately 490 million are infected with HSV-2 worldwide. Despite being preventable, HSV transmission rates remain high as most HSV carriers are unaware of their serostatus owing to the lack of a robust HSV diagnostic suitable for routine population-based screening. Current HSV diagnostics are typically limited to active infections with high viral loads (viral culture and swab-based assays) and have low specificity resulting in false or equivocal test results (serology tests). Rational vaccines is developing a novel HSV type-specific multiplex assay that will provide improved sensitivity and specificity compared to current HSV diagnostic tests. The objective of this phase i proposal is to develop and complete proof-of-concept studies for a novel assay for detecting antibodies against HSV-2 in human sera. This innovative assay will fulfill an unmet clinical need for accurate type-specific HSV detection.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Original award | $291,480 |
Quick answers
Who received award R43AI176913?
R43AI176913 was awarded to Rational Vaccines Inc. by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on August 1, 2023.
How much is award R43AI176913 worth?
$291,480 has been obligated on R43AI176913.
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