Improved methods and commercialization of a multimodal vibrating sharp-edge spray ionization source
Active Project Grant Awarded Last action
- Award ID
- R42GM142379
- Recipient
-
Invibragen Inc. UEI H6U3AQDR4367
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $2,076,901
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date 91% complete
- Place of performance
- Morgantown, WV, USA
Award details come from USAspending.gov.
Description
- Abstract
- / summary over the last 20 years, mass spectrometer instruments have developed at a remarkable pace. Improvements in instrument design have led to significant advances in overall performance with regard to sensitivity, mass range, and throughput. Today, many high-end mass spectrometers feature all of these design enhancements trending toward the ability to use a single instrument for highly varied experiments ranging from native mass spectrometry (MS) and untargeted metabolomics. Currently, three spray-based ionization sources dominate the market for high-end mass spectrometers. These sources are: heated electrospray ionization (hesi), nanoelectrospray ionization (nesi), and atmospheric pressure chemical ionization (apci). A problem arises in that each is required for different types of experiments. Thus, the true potential of the mass spectrometer especially with regard to throughput is often hindered. This proposal will result in the development of an all-in- one ionization source that can replace all three sources while at the same time providing superior performance with regard to sensitivity and throughput for a wide variety of experiments. The new ionization source is based on the vibrating sharp-edge spray ionization (vssi) technology invented in DR. LI's research group at west virginia university (WVU). The phase i sttr work produced a prototype source for native MS experiments that provided sensitivity enhancements of 10 to >100-fold over hesi and nesi. The phase II work will create a foolproof (turn-key) ionization source to allow scientists to take advantage of the sensitivity gains. Additionally, novel functionality will be included in this three-in-one ionization source to allow for unique experiments such as turning protein stabilities in droplets and monitoring protein structure flexibility and changes in such. Another example is the introduction of cyclical vssi/apci capabilities in a single experimental sequence which will allow broader and deeper metabolomics and lipidomics characterizations. The invibragen spanda multimodaltm ionization source will unlock the full potential of high-end mass spectrometers while providing significant cost savings to the customer.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $929,549 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Original award | $1,147,352 |
Quick answers
Who received award R42GM142379?
R42GM142379 was awarded to Invibragen Inc. by National Institute of General Medical Sciences (National Institutes of Health) on September 1, 2021.
How much is award R42GM142379 worth?
$2,076,901 has been obligated on R42GM142379.
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