Project Grant R42ES026245

This $500,000 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program aims to develop a novel human stem cell-based microfluidic developmental toxicology platform. The University of Michigan will receive funding from September 2022 to August 2024 to conduct technological development of a repeatable, controllable, high-throughput microfluidic system for generating three-dimensional multicellular organoid models for toxicity testing. The platform seeks...

The National Institute of Environmental Health Sciences (NIEHS) awarded Xcellassay, Inc. a $306,872 Project Grant under the Environmental Health (CFDA 93.113) federal grant program. The grant funding will support the development and characterization of a hand-held, bioassay-based test strip for rapid, in-field detection of water contamination by endocrine-disrupting chemicals (EDCs). The goal is to create a 1 x 1.5 cm detection strip printed with 20 nuclear receptor sensors that can be...

Ortuvo LLC received a $256,000 Project Grant award from the National Science Foundation on June 1, 2021 to develop a fully screen printed electric cell-substrate impedance sensing toxicity assay. The award is part of the NSF's Technology, Innovation, and Partnerships program (CFDA 47.084), which seeks to advance science, engineering, and innovation leading to breakthrough technologies and solutions to national challenges. Under the one-year project period ending November 30, 2022, Ortuvo will...

This Project Grant from the National Institutes of Health's National Cancer Institute totaling $668,151 will support the development of highly multiplexed live-cell G protein-coupled receptor (GPCR) arrays for glioma drug discovery. Spectragenetics, Inc. will deploy an automated multiplexed live-cell assay to detect and quantify agonist and inverse-agonist activities against 55 GPCRs known to be upregulated or downregulated in human gliomas. The assay will be used to screen 48 established...

Federal Grant Award Summary Attogene Corporation received a $257,312 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), with an award date of August 26, 2025, and completion date of June 30, 2026. The award funds the development of a novel electrochemical biosensor designed to detect organophosphate and carbamate (OPAC) pesticide residues. The sensor leverages recombinant acetylcholinesterase (AChE)...

Federal Grant Award Summary Bioprinting Laboratories Inc. received a $306,872 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded July 8, 2025, with completion targeted for October 31, 2026. The company is developing a high-throughput screening platform for assessing developmental neurotoxicity (DNT) in commercially used chemicals. The primary deliverable is an engineered system combining genetically...

Federal Cooperative Agreement Summary Chromologic LLC received a $533,384 Cooperative Agreement award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective September 2, 2025, with completion targeted for August 31, 2030. The award funds the validation and advancement of the MIDOS assay, a microRNA (miRNA)-based predictive diagnostic tool designed to pre-symptomatically identify patients at risk for...

Khloris Biosciences, Inc. received a $3.46 million Project Grant from the National Institutes of Health National Heart, Lung and Blood Institute to develop and validate a collection of induced pluripotent stem cell-derived cardiomyocyte cell lines. Under the Cardiovascular Diseases Research program (CFDA 93.837), Khloris will establish 50 cell lines from healthy individuals and patients with common hereditary cardiac disorders such as hypertrophic cardiomyopathy, dilated cardiomyopathy, and long...

This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $459,353 to the University of Toledo to conduct research on the discovery and characterization of novel cyanotoxins produced during harmful cyanobacterial blooms. The key objectives are to: 1) optimize high-performance liquid chromatography (HPLC) with native fluorescence detection and mass spectrometry (MS/MS) for structural...

This $440,000 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research at Northwestern University to create an unbiased and global map of the cellular response to environmental proteotoxic stress. The project will integrate cutting-edge chemical-genetic screening with computational analysis to identify critical components, functions, and regulatory nodes in the proteostasis network that cells...