HBI-002 to treat parkinson?s disease
Ended Project Grant Awarded Last action
- Award ID
- R41NS122576
- Recipient
-
Hillhurst Biopharmaceuticals, Inc. UEI G5YJYCGDUZD7
- Awarding agency
-
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,720,982
Award facts
- Assistance listing
- 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders
- Completion date
- Originally
- Funding
-
- $1,267,824.00 Federal
- $453,158.00 Non-federal
- Place of performance
- California, USA
Award details come from USAspending.gov.
Description
- Abstract
- The goal of the proposed project is to evaluate the potential of HBI-002, a novel oral formulation of carbon monoxide (CO), as a neuroprotective agent in parkinson's disease (PD). A growing body of research suggests that low doses of CO - and the heme oxygenase (HO) enzymes that generate endogenous CO - protect against neuronal cell loss in PD, and epidemiologic studies have associated cigarette smoking with a lower risk of PD. Together, these observations suggest that low doses of CO may be neuroprotective in PD. Nicotine does not appear to underlie the protective effect of tobacco, as a clinical study of nicotine in PD did not show significant improvement. At low levels (
Transactions
| Action | Federal | Non-federal | Date |
|---|---|---|---|
| Amendment | $0 | $0 | |
| Amendment | $180,754 | $0 | |
| Amendment | $180,754 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $453,158 | $0 | |
| Original award | $453,158 | $453,158 |
Quick answers
Who received award R41NS122576?
R41NS122576 was awarded to Hillhurst Biopharmaceuticals, Inc. by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on September 20, 2021.
How much is award R41NS122576 worth?
$1,720,982 has been obligated on R41NS122576: $1,267,824 in federal funding and $453,158 in non-federal funding.
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