Project Grant R41HG013624
- This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), will provide $215,088 to Directseq Biosciences, Inc. to develop an exhaustive de novo RNA sequencing method using next-generation mass spectrometry (NGMS-seq). The objective is to create a technology that can directly identify and sequence every RNA species in a sample, while also comprehensively profiling all RNA modifications, without bias....
- This $383,482 Project Grant, awarded on June 6, 2025 by the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research), aims to develop SPINSEQ, an innovative RNA sequencing platform capable of precise and accurate transcriptomic analysis. The project, conducted by Electronic Biosciences, Inc., a small biotechnology company in San Diego, California, focuses on maintaining RNA integrity and enabling improved detection of RNA modifications through advanced sequencing...
- The federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,507,500 to the University of Massachusetts Medical School (UMass Medical) to expand the capabilities of third-generation DNA/RNA sequencing technologies. The project aims to generate rapid and cost-effective training libraries to allow for direct detection of common DNA damage and RNA modifications, enabling innovative...
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $384,418 Project Grant to Xgenomes Corp. on September 25, 2024 to develop a revolutionary DNA sequencing platform. The project aims to create a super-resolution single-molecule sequencing technology that can read short sequence "words" rather than individual nucleotides, enabling one or more orders of magnitude improvements in accuracy and cost over...
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded Evizia Inc. a $1,234,692 project grant on April 7, 2025. The grant supports the development of a novel biomolecule desktop imaging system called PRECYSE, which uses high-speed atomic force microscopy (HSAFM) to provide improved quality control for next-generation sequencing (NGS) sample preparation. The PRECYSE system can rapidly size DNA samples from 100 base...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $350,000 to Electronic Biosciences, Inc. to develop the first technology capable of high-accuracy sequencing of the RNA modifications pseudouridine (Ps) and N6-methyladenosine (M6A) using nanopore sequencing. The project aims to merge innovative bisulfite adduct methodology with Electronic Biosciences' enzyme-free, multipass...
- The National Human Genome Research Institute (NHGRI), under the Federal Grant Program "Human Genome Research" (CFDA 93.172), awarded a $407,291 Phase I Small Business Innovation Research (SBIR) grant to Electronic Biosciences, Inc. to develop a nanopore-based protein sequencing platform. The project aims to create a high-accuracy, label-free nanopore reader capable of direct, single-molecule protein sequencing. This novel technology would enable proteome-wide profiling, biomarker...
- The National Human Genome Research Institute (NHGRI), under the Federal Grant Program for Human Genome Research (CFDA 93.172), awarded a $397,599 Project Grant to Xgenomes Corp. in Cambridge, MA. The grant supports the development of a novel epigenetic analysis method that can directly detect DNA methylation patterns across the genome with high accuracy, overcoming limitations of current sequencing techniques. The project aims to create advanced molecular analysis platforms that leverage machine...
- The National Human Genome Research Institute (NHGRI) awarded a $291,232 Project Grant to Micropure Genomics Inc. on September 17, 2025 under the Human Genome Research Federal Grant Program (CFDA 93.172). The project aims to develop an automated, bead-less, and gel-less microfluidic size selection approach to simplify workflows, reduce costs, and enhance the performance of long-read DNA sequencing technologies such as PacBio and Oxford Nanopore. The proposed innovation, called mPREP, leverages...
- This federal Project Grant award of $350,000 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of a neural network-accelerated DNA and RNA sequence processing node, called CLEDGESEQ, for use in field, clinical, and industrial settings. The project aims to create advanced sequence analysis and communication capabilities for edge applications, enabling cost-effective and scalable DNA/RNA...
This federal Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research CFDA program (93.172), provides $406,500 to Directseq Biosciences, Inc. to advance next-generation mass spectrometry-based sequencing (NGMS-SEQ) methods. The primary objectives are to 1) develop high-throughput NGMS-SEQ techniques for direct sequencing of transfer RNA (tRNA) samples, including physiologically relevant ones, and 2) enhance technologies to quantitatively map tRNA modifications site-specifically and track their dynamic changes within a melanoma model. This award aims to overcome challenges in comprehensive sequencing of RNA modifications, which are central to functional diversity, cellular regulation, and diseases like cancer and neurological disorders. The refined NGMS-SEQ techniques initially tailored for tRNA have the potential to extend to longer RNAs and small non-coding RNAs, providing vital insights into RNA-associated diseases. The award period is from Sep 18, 2024 to Aug 31, 2025.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $406.5k | 9/18/24 |