Project Grant R41HD102268

The National Institute of Child Health and Human Development (NICHD) awarded CX Therapeutics, Inc. a $2,283,054 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop a novel medical device for treating cervical insufficiency in pregnant women. The CX device is designed to improve upon the current standard of care, cervical cerclage, by providing more uniform compression around the cervix to better retain the pregnancy and prevent...

This Project Grant awarded by the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $304,452 to 3VO Medical, Inc. to develop a minimally invasive intrauterine labor augmentation system (ILAS). The ILAS aims to directly increase labor forces and relieve uterine muscle demand during childbirth, addressing the issue of prolonged stage I active labor experienced by 20% of low-risk deliveries in the U.S. annually. The Phase I...

This $429,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to determine if blood perfusion and microvascular pressure around the internal os of the uterine cervix can distinguish patients with a history of cervical insufficiency (CI) from normal controls in a non-pregnant state. The researchers at Thomas Jefferson University will use contrast-enhanced...

This federal Project Grant award of $308,526.00 from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Program (CFDA 93.837), aims to develop a novel device for uterine hemostasis (stoppage of bleeding) after cesarean section procedures. The funded project seeks to finalize design parameters, validate materials, and conduct functional performance testing for this novel system, with the goal of enabling an early feasibility trial. Cesarean...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded Akna Health Inc. a $151,600 Project Grant (CFDA 93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) to develop a point-of-care diagnostic solution for early identification of high-risk pregnancies. The research aims to validate the clinical relevance of cervical biomarkers as predictors of perinatal complications, such as fetal growth restriction, miscarriage, and...

This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $343,510 to Theranova LLC, a veteran-owned medical device company based in San Francisco, to conduct a pilot clinical study evaluating the SOLESTIM neuromodulation system as a treatment for dysmenorrhea (menstrual cramps). The SOLESTIM system is a portable, non-invasive device that uses plantar...

The National Institute of Child Health and Human Development (NICHD) awarded a $383,114 Small Business Innovation Research (SBIR) Phase I project grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Venova Technologies Inc., a women-led and minority-led medical device startup company. The grant funds the development of a novel, non-hormonal, long-acting female contraceptive device designed to address the critical unmet need for birth control options without hormonal...

This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) totaling $1,459,877 will support research to develop a bioinspired composite scaffold for repairing pubovisceral muscle enthesis (PVME) injuries, which can lead to pelvic organ prolapse in women. The research will involve three main components: Investigating the structure and function of native PVME and...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $903,453 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Vortex Medical Inc. for the development of a novel fetal vesico-amniotic shunt (VAS) to treat fetal lower urinary tract obstruction (LUTO). The proposed device incorporates enhanced anchors, improved ultrasound visibility, and a reinforced channel to address the high dislodgement rate and...

This Project Grant award from the National Institute of Neurological Disorders and Stroke, under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $384,923 to Lumina Medical LLC to develop an innovative, girth-adjustable vaginal dilator with precise dilation monitoring. The goal is to significantly improve pain management for patients with pelvic floor disorders and vaginal conditions. The key products to be delivered include: A 3D printed prototype and injection-molded...