A novel method for improved separation of metagenomic samples for preservation and identification
Ended Project Grant Awarded Last action
- Award ID
- R41GM140530
- Recipient
-
Syracuse Biolabs, Inc. UEI QAW2G2NJY562
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $656,538
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date
- Funding
-
- $437,692.00 Federal
- $218,846.00 Non-federal
- Place of performance
- New York, USA
Award details come from USAspending.gov.
Description
- Abstract
- The success of all microbiome-based studies are highly dependent on effective sample purification of the target organisms of interest. Characterizing individual organismal components of these metagenomic samples relies heavily upon the ability to separate the individual phylogenetic components, such as removing human cells from the microbiological fraction while preventing samples loss or degradation. This phase i sttr project aims to significantly advance DNA purification methods of metagenomics / environmental samples (e.g. human and bacteria) using a patent pending simple and inexpensive purification approach aimed at effectively separating and preserving host and microbial DNA. This method will ensure all organismal DNA is preserved (i.e. not "sacrificed" or loss) during initial separation steps, unlike protocols employed by existing DNA purification kit manufacturers. Outcomes should result in higher quality DNA sequence data (i.e. higher sequencing coverage and higher sensitivity) thus providing robust information content, leading to higher confidence in the organismal characterization. Syracuse biolabs, INC. (SBL), has teamed with scientists in the forensic and national security sciences institute (fnssi) at syracuse university to further improve and commercialize this novel DNA purification approach. This phase i project has three aims directed to establish a proof-of-concept of the method leading to initial kit development for fieldable DNA purification modules of metagenomic samples. Our metagenomics DNA purification kit is also applicable to fields outside of the human microbiome research market, including forensic identification and geolocation of biological samples relevant to criminal and intelligence related activities, DNA based ecological research, plant and microbial based geosourcing and defense/homeland security efforts (requiring DNA purification from environmental samples).
Transactions
| Action | Federal | Non-federal | Date |
|---|---|---|---|
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $218,846 | $0 | |
| Original award | $218,846 | $218,846 |
Quick answers
Who received award R41GM140530?
R41GM140530 was awarded to Syracuse Biolabs, Inc. by National Institute of General Medical Sciences (National Institutes of Health) on September 15, 2021.
How much is award R41GM140530 worth?
$656,538 has been obligated on R41GM140530: $437,692 in federal funding and $218,846 in non-federal funding.
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