Project Grant R41ES038417
- The National Institute of Environmental Health Sciences awarded $612,748 to Luxbiome Inc. on September 12, 2025, under the Environmental Health program (CFDA 93.113) to develop microbiome-based solutions for reducing inorganic arsenic exposure and body burden. The project will optimize human gut bacterial strains and evaluate their efficacy and safety in reducing arsenic uptake, methylation, and efflux through in vitro screening and in vivo modeling. Specific aims include screening bacterial...
- The National Institute of Environmental Health Sciences awarded Worcester Polytechnic Institute $400,753 on July 1, 2026, under the Environmental Health program (CFDA 93.113) to develop engineered probiotic bacteria for lead toxin elimination. The award funds research into cost-effective methods to reduce lead exposure and cumulative lead poisoning, which disproportionately affects low-income communities and causes permanent neurotoxic effects, neurodevelopmental anomalies in children, and...
- The National Institute of Environmental Health Sciences awarded Biota Inc. $306,585 under the Environmental Health grant program (CFDA 93.113) on July 1, 2026, to develop an automated nanoparticle-based sample preparation platform for per- and polyfluoroalkyl substances (PFAS) analysis. The Phase I project establishes feasibility of a fully automated workflow that replaces labor-intensive solid-phase extraction methods in PFAS monitoring. The platform integrates advanced nanoparticle chemistry...
- The National Institute of Environmental Health Sciences awarded the University of Texas Medical Branch at Galveston $718,775 on April 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate the role of gut microbiota dysbiosis in trichloroethene-mediated autoimmunity and systemic lupus erythematosus induction. The project, titled "Understanding the Role of Gut Microbiome in Trichloroethene-Mediated Autoimmunity," examines how trichloroethylene (TCE) exposure in...
- This federal Project Grant award of $445,240.00 was provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health federal grant program (CFDA 93.113) to the Icahn School of Medicine at Mount Sinai. The grant supports a research project investigating the complex interactions between prenatal metal exposures, gut microbiome composition, and telomere length attrition in childhood. The long-term goal is to better understand how environmental exposures and...
- The National Institute of Environmental Health Sciences awarded Nanohmics Inc. $313,365 on August 1, 2026, under the Environmental Health program (CFDA 93.113) to develop a handheld fluorescent lysosomal yeast biosensor for detecting toxic metal ions and organic pollutants in water. Nanohmics will advance a yeast-based toxicity detection system that exploits the principle that yeast cell vacuoles respond like human lysosomes by acidifying, swelling, and increasing in numbers when exposed to...
- The National Institute of Environmental Health Sciences awarded the University of Memphis $506,270 under the Environmental Health Project Grant program (CFDA 93.113) on April 17, 2026, to investigate how disruption of the oyster microbiome influences bioaccumulation of polycyclic aromatic hydrocarbons and pathogenic Vibrio species in oyster tissues. Research will employ antibiotic-induced microbiome perturbation, contaminant and pathogen quantification, 16S rRNA gene sequencing, and oyster...
- The National Institute of Environmental Health Sciences awarded the University of Rochester $415,613 under the Environmental Health program (CFDA 93.113) on February 24, 2026, to investigate how pregnancy and the maternal gut microbiome influence methylmercury metabolism and elimination in pregnant women and fetuses. The research optimizes previously developed tools to monitor methylmercury metabolism and excretion in non-pregnant adults, applying them to pregnant women who consume fish...
- The National Institute of Environmental Health Sciences awarded The Medical College of Wisconsin, Inc., $706,420 on August 1, 2026, under the Environmental Health program (CFDA 93.113) to develop and test Gegoo Myaajyang Gkendmang (Knowing What We Eat), a mobile application designed to reduce dietary exposure to chemical contaminants in Great Lakes Anishinaabe communities. The award funds characterization of dietary patterns and quantification of contaminants in local and subsistence foods...
- The National Institute of Environmental Health Sciences awarded $1,037,876 to Amelia Technologies LLC on June 22, 2026, under the Environmental Health program (CFDA 93.113) to develop and commercialize the ECOWELL platform, a modular micro-incubation system for K–12 environmental science education. ECOWELL is a programmable six-well incubation platform that enables students to simulate and analyze complex environmental scenarios by independently controlling and measuring temperature, ultraviolet...
The National Institute of Environmental Health Sciences awarded $306,373 to Luxbiome Inc. on August 24, 2026, under CFDA 93.113 (Environmental Health) to develop microbiome-based solutions for reducing lead exposure in the human body. The project targets the gut microbiome's role in lead metabolism, leveraging preliminary identification of nine bacterial strains that significantly reduce lead tissue accumulation in mice. The approach addresses lead exposure from multiple sources—soil, water, air, food, and industrial products—where conventional water filtration methods prove inadequate. The objective is to engineer custom microbiomes that enhance the body's natural lead removal capacity through ingestion-based intervention, addressing lead exposure pathways that existing commercial methods do not cover. Luxbiome Inc., based in Cary, North Carolina, performs the work under a period of performance from August 24, 2026, through July 31, 2027. This is a Phase I SBIR project grant, which in the Environmental Health program are evaluated on soundness of the proposed approach, qualifications of the principal investigator and supporting staff, technological innovation, potential for commercial application, budget appropriateness, facility adequacy, and safeguards for human or animal subjects and environmental protection.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $306.4k | 8/21/26 |