Project Grant R41DA064269
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Pittsburgh a $434,005 R21 Exploratory/Developmental Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate xylazine toxicity and develop therapeutic interventions. The award, dated May 15, 2026, with a completion date of April 30, 2028, addresses a critical public health gap by identifying the pharmacological mechanisms of xylazine—a non-opioid drug increasingly...
- This $387,750 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research by Mercer University to investigate the molecular pharmacology of the drug xylazine and its effects on adrenoceptors. The research aims to assess xylazine's binding affinity and functional profiles at different adrenoceptor subtypes expressed in vascular smooth muscle cells, as well as directly test the hypothesis that...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Johns Hopkins University a Project Grant totaling $193,854 under the Drug Use and Addiction Research Programs (CFDA 93.279) for the period September 1, 2025 through August 31, 2027. This pilot study will generate rigorous epidemiologic data on xylazine use and associated health harms among people who inject drugs in the Baltimore area. Xylazine, a veterinary sedative increasingly prevalent in the...
- Federal Grant Award Summary The Scripps Research Institute received a $506,000 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded July 15, 2025, with completion scheduled for June 30, 2027. The project focuses on the preparation and investigation of monoclonal antibodies designed to block xylazine's mechanism of action and mitigate its adverse effects. Xylazine, a veterinary sedative increasingly detected as an...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $423,500 Project Grant to the Regents of the University of Minnesota, Office of Sponsored Projects Administration, effective June 1, 2026 through May 31, 2028, under the Drug Use and Addiction Research Programs (CFDA 93.279). This award funds preclinical neuropharmacological research investigating the interactions between xylazine, a 2-adrenergic receptor (2AR) agonist increasingly incorporated into illicit...
- Federal Grant Award Summary Praeventix LLC received a $355,190 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded June 1, 2026, with completion by May 31, 2027. The grant supports in vivo characterization of 5-HT7 modulators in rat models of opioid use disorder (OUD). Specifically, Praeventix will conduct preclinical studies to evaluate the efficacy of novel 5-HT7 antagonists, including the lead compound...
- Federal Grant Award Summary Yale University received a $197,024 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 30, 2025, with a completion date of June 30, 2027. The grant funds two multi-methods research studies examining the impact of xylazine, a veterinary tranquilizer emerging as an adulterant in the unregulated opioid supply, on people who use drugs (PWUD). The first study, conducted in North...
- This Project Grant award for $423,708 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The funding will support research to investigate the effects of fentanyl-xylazine drug mixtures on cardiorespiratory function and subjective effects in rats. Specifically, the research aims to characterize how xylazine impacts fentanyl-induced changes in heart rate, blood pressure, temperature, and respiration, as well as determine if...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $587,174 Project Grant to The Regents of the University of California, San Francisco under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a two-year research study titled "TRANQ Burn: The Acidity of Xylazine and Fentanyl Combinations." The award, effective September 1, 2025 through August 31, 2027, supports an investigation into the mechanisms by which the acidity of xylazine and...
- Federal Grant Award Summary Rescue Biomedical, LLC received a $799,430 Phase I Small Business Innovation Research (SBIR) Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), with an award date of August 1, 2025 and completion date of July 31, 2026. The award supports the development and commercialization of the Automatic Detection Device (AD2), a user-centric wearable detection module designed to identify...
EDI Therapeutics LLC received a $274,219 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective June 1, 2026 through May 31, 2027. The project aims to develop and test Chimectin, a first-in-class fibronectin matrix mimetic biologic, as a topical therapeutic for healing xylazine-induced skin injuries. Xylazine, an animal sedative increasingly used as an adulterant in illicit opioids, causes severe skin ulceration and necrosis through vasoconstrictive mechanisms. The recombinant fibronectin fragment stimulates local vasodilation and revascularization to accelerate wound healing. Under this award, EDI Therapeutics will formulate Chimectin for topical application and evaluate its efficacy in a preclinical ischemic skin ulcer model at three concentration levels (10, 20, and 40 millimolar) to simulate xylazine-induced vascular damage. The research will include stability and performance testing of the formulation to establish a foundation for advancing Chimectin toward clinical development. Successful completion of these objectives would provide evidence supporting clinical advancement for treatment of xylazine-induced and other chronic skin wounds, addressing a critical unmet medical need within the opioid epidemic context.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $274.2k | 6/1/26 |