Project Grant R41DA064189
- Federal Grant Award Summary The National Institute on Drug Abuse awarded Texas Biomedical Research Institute a Project Grant of $1.14 million under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct targeted CRISPR/Cas genome editing research aimed at eliminating Simian Immunodeficiency Virus (SIV) central nervous system (CNS) reservoirs in methamphetamine-exposed rhesus macaques receiving antiretroviral therapy (ART). The award, granted on August 15, 2025, with a completion...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Johns Hopkins University a Project Grant totaling $668,423 under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct integrated research on microglial mechanisms in HIV persistence and methamphetamine-induced neuroinflammation. The award, effective April 15, 2026 through March 31, 2028, funds the development of advanced human-derived neuroimmune platforms and multi-omics analyses to...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $648,389 to the Oklahoma Medical Research Foundation (OMRF) on February 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct basic neuroscience research on methamphetamine use disorder. The project, which extends through November 30, 2030, focuses on identifying cell type-specific neurotensin signaling mechanisms in the brain that modulate methamphetamine self-administration behavior....
- Federal Grant Award Summary The Scripps Research Institute received a $608,652 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective September 1, 2025, through May 31, 2030. This award supports a data mining and functional validation initiative focused on the SCORCH (Substance use, Comorbidity, and Opportunities for Recovery and Cognitive Health) datasets. The project will conduct comparative analysis of cell...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Icahn School of Medicine at Mount Sinai a $2.352 million Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) on February 15, 2026, with a completion date of January 31, 2030. This award funds neurogenomic research investigating molecular alterations in the brains of individuals living with HIV (Human Immunodeficiency Virus) who have concurrent opioid or substance use disorder (OUD/SUD). The...
- Federal Grant Award Summary Oregon Health & Science University (OHSU) received a $1,247,300 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective September 30, 2025, with completion targeted for May 31, 2030. The award funds research investigating thyroid hormone-mediated reprogramming of the basolateral amygdala (BLA) in response to adolescent social deprivation and its relationship to substance use...
- Federal Grant Award Summary Jillion Therapeutics Inc. received a $398,093 Phase I Small Business Innovation Research (SBIR) Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) to identify and develop therapeutic compounds for treating amphetamine use disorders. The award, effective July 1, 2025, through June 30, 2027, supports the company's use of proprietary DNA-encoded library (DEL) technology to discover drug-like...
- Federal Project Grant Award Summary Oregon Health & Science University (OHSU) received a $906,124 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective September 1, 2025, through May 31, 2030. The award supports basic neuroscience research investigating the cellular mechanisms underlying opioid tolerance—a critical clinical problem in pain management where prolonged opioid use requires increasing dosages...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Massachusetts Medical School a $1.74 million Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning July 15, 2025, with completion targeted for March 31, 2030. This award supports research focused on the discovery and functional characterization of long non-coding RNAs (lncRNAs) in opioid use disorder (OUD) within the context of HIV at single-cell resolution. The...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $9.33 million Project Grant to The Regents of the University of California, San Francisco under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct in vivo imaging and post-mortem research examining the impact of methamphetamine (MA) use on immune dysfunction and HIV reservoir transcription among people with HIV on antiretroviral therapy (ART). The award, effective July 15, 2025 through May 31,...
Virogenomics Biodevelopment, Inc., a woman-owned small business based in Tigard, Oregon, received a $399,889 Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) effective June 1, 2026, through May 31, 2027. The award supports preclinical research evaluating DRHQ, a novel third-generation immunotherapeutic compound designed to regulate CD74 (cluster of differentiation 74) signaling and reduce central nervous system (CNS) damage caused by non-disordered drug use, specifically methamphetamine exposure. The research will investigate whether DRHQ can decrease infarct volume and improve cognitive function in methamphetamine-associated stroke models and examine the compound's effects on axonal dysfunction in myelinated and unmyelinated fibers within the corpus callosum. This award builds on Virogenomics' established research program targeting methamphetamine use disorder through CD74 modulation. The company's previous work demonstrated that DRHQ and related MHC (major histocompatibility complex) Class II constructs improve cognitive function and reduce inflammation in animal models of methamphetamine exposure, stroke, and multiple sclerosis. The current grant deliverables include completion of animal model studies demonstrating DRHQ's therapeutic potential for reversing neuronal and axonal damage, thereby advancing the compound toward future clinical development and supporting the broader national research agenda on substance use, addiction, and related health outcomes.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $399.9k | 5/27/26 |