Project Grant R41CA298020

Award Date 6/9/25
Completion Date 5/31/26
Dollars Obligated $399K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Florida, USA
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This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $398,997 to Immunogenik, Inc. to advance the development of a novel cancer immunotherapy targeting the LAIR1 immune checkpoint. The key products and services delivered under this award include:

  1. In vitro validation of a humanized anti-LAIR1 antibody (Hu-aLAIR1) to assess binding affinity, specificity, stability, and functional activity in blocking LAIR1-mediated immunosuppression using patient-matched tumor explants.

  2. Conducting efficacy studies of Hu-aLAIR1 in tumor-bearing mice to evaluate pharmacokinetics, dose-response relationships, and anti-tumor efficacy, with the goal of identifying the maximum tolerated dose with optimal therapeutic benefit.

  3. Pilot safety and toxicology testing to establish a no-observed-adverse-effect level (NOAEL) and complete the GLP-compliant protocol design for future Phase II clinical studies.

This project aims to advance the development of Hu-aLAIR1 as a promising cancer immunotherapy that can overcome resistance to PD-1 blockade by targeting the novel LAIR1 immune checkpoint expressed on tumor-associated macrophages. The ultimate goal is to translate these research findings into early-phase clinical trials and eventual commercialization to deliver innovative treatments to cancer patients.

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