Development of lysosome targeted therapeutics
Ended Project Grant Awarded Last action
- Award ID
- R41CA271967
- Recipient
-
Majestic Therapeutics, LLC UEI D34CNHJJ2UE4
- Awarding agency
-
National Cancer Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $258,981
Award facts
- Assistance listing
- 93.395 Cancer Treatment Research
- Completion date
- Originally
- Place of performance
- Oro Valley, AZ 85755, USA
Award details come from USAspending.gov.
Description
- Abstract
- Lysosomal proteolysis facilitates the turnover of organelles and selected long-lived proteins and is a critical regulator of cellular homeostasis. Its aberrant activation promotes drug resistance and cancer progression by generating alternative sources of survival sustaining metabolic fuel to cells that are stressed by hypoxia, radiation, chemotherapy, and targeted agents. Despite its clear potential as a therapeutic target, no intentionally designed targeted inhibitors of lysosomal function have been FDA approved to date. We recently generated a series of novel orally available lysosomal disrupting agents with favorable safety profiles and single agent therapeutic activity. Our first lead HIT is active against acute myeloid leukemia (AML) cells with high-risk features and augments the efficacy of azacitidine to significantly extend overall survival in mouse models of AML. Our major goal is to use medicinal chemistry approaches to optimize its pharmacologic properties to develop a novel lysosomal proteolysis inhibitor that can be commercialized for the treatment of patients with AML and other diseases where aberrant pathway activity contributes to pathogenesis.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | -$257,701 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $258,341 | |
| Original award | $258,341 |
Quick answers
Who received award R41CA271967?
R41CA271967 was awarded to Majestic Therapeutics, LLC by National Cancer Institute (National Institutes of Health) on July 1, 2022.
How much is award R41CA271967 worth?
$258,981 has been obligated on R41CA271967.
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