Development of a biomarker panel for screening and early detection of gynecological cancers
Ended Project Grant Awarded Last action
- Award ID
- R41CA257115
- Recipient
-
Mddx Inc. UEI PNGNTAMC9EE9
- Awarding agency
-
National Cancer Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,199,916
Award facts
- Assistance listing
- 93.394 Cancer Detection and Diagnosis Research
- Completion date
- Originally
- Funding
-
- $799,944.00 Federal
- $399,972.00 Non-federal
- Place of performance
- New York, NY 10065, USA
Award details come from USAspending.gov.
Description
- Abstract
- IT is estimated that more than 80,000 women will be diagnosed with ovarian (ovca) and endometrial (endoca) cancers this year in the U.S. And this will result in the death of 26,000 women. There are no screening tests for either of these two female-specific cancers which also disproportionally affect ethnically distinct populations. For both cancers, detection of early stage, localized disease is associated with 5-year survival rates in excess of 90%, while diagnosis with late stage, metastatic disease results in dramatically reduced 5-year survival rates of ~25%. Mddx, INC. Has been leveraging access to >12 years of longitudinally collected and deeply annotated biobanked plasma samples from the gynecologic cancer translational research program (icahn school of medicine at mount sinai; new york, NY and nuvance health; danbury, CT) to identify tumor-associated autoantibodies (AAB) that could serve as diagnostic biomarkers. By performing AAB profiling against the entire human proteome and applying our novel machine-learning based method for classification of molecular profiles we have determined that classification signatures of
Transactions
| Action | Federal | Non-federal | Date |
|---|---|---|---|
| Amendment | $0 | $0 | |
| Amendment | $399,972 | $0 | |
| Original award | $399,972 | $399,972 |
Quick answers
Who received award R41CA257115?
R41CA257115 was awarded to Mddx Inc. by National Cancer Institute (National Institutes of Health) on September 1, 2021.
How much is award R41CA257115 worth?
$1,199,916 has been obligated on R41CA257115: $799,944 in federal funding and $399,972 in non-federal funding.
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