This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $210,867 to Drexel University to develop a cell-based therapy for generating donor-specific immune tolerance in kidney transplant recipients. The key goal is to engineer potent tolerogenic dendritic cells (toldcs) that can be infused into donor kidneys prior to transplantation. These engineered toldcs will...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,310,631.89 in funding to Yale University to develop and evaluate targeted nanoparticle drug delivery systems for preventing early transplant rejection. The key objectives are to: 1) Develop antibody-targeted, degradable nanoparticles that can selectively deliver therapeutic siRNAs to graft endothelial cells to...
The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded a $300,000 Project Grant to Electronic Biosciences, Inc. to develop a novel point-of-care technology for monitoring immunosuppressant drug levels. The key product being developed is a portable, fingerstick-based testing system that can provide convenient and frequent immunosuppressant drug level measurements. This will enable more precise dosing for...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,470,094.00 to New York University (NYU) School of Medicine to develop AI-assisted interpretation of preimplantation kidney transplant biopsies. The project aims to: 1) construct a comprehensive histopathology atlas using self-supervised and expert-supervised learning on over...
This federal Project Grant award in the amount of $1,648,086 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to develop new therapies and technologies for inducing immune tolerance in kidney transplant recipients. The research focuses on using CD20-targeted CAR T cell therapy to deplete B cells and modify the B and T cell repertoire in a non-human primate model of kidney transplantation. The goal...
This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports the development of a novel microfluidic platform for high-performance sorting of immune cells based on their distinct secretion patterns. The total funding amount is $1,269,762, awarded on December 9, 2024, with a project period ending on November 30, 2029. The key objectives of this project are to...
This Project Grant award, valued at $219,792.00 and running from March 2025 to February 2027, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports the development of statistical methods to analyze high-throughput T-cell receptor sequencing (TCR-seq) data. The goal is to enable more meaningful interpretation of TCR profiling measurements, which provide critical insight into an...
This federal Project Grant award of $4,433,050.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports a randomized controlled trial to evaluate the effects of pre-implantation, intrarenal artery injection of C1 esterase inhibitor on kidney transplant outcomes. The award aims to determine if this novel therapeutic approach can improve allograft function and reduce ischemia-reperfusion injury in deceased donor kidney...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to identify microbial biomarkers that can predict multi-drug resistant organism (MDRO) colonization in solid organ transplant recipients. The $841,520 award will leverage an existing cohort and biobank of over 2,200 samples to generate whole-genome sequencing of infectious isolates and metagenomics...
This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to identify cellular and molecular targets for developing tissue/cell-specific strategies to prevent cytomegalovirus (CMV) reactivation and improve kidney transplant outcomes. The $775,986 award, with a performance period from January 1, 2025 to December 31, 2025, will support research conducted by...