This $634,881 federal Project Grant (R01AI181023) was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project aims to develop a first-in-class microfluidic platform for high-performance sorting of immune cells based on their distinct secretion patterns. The SECRE (Secretion-Enabled Cell Ranking and Enrichment) platform will be used to identify genetic regulators of immune cell secretion, such as IL-2, CXCL13, and IL-10, to enhance the potency of T cells, NK cells, and regulatory B cells. This technology is expected to significantly advance the understanding and control of immune responses, accelerating the development of effective therapeutics for immune diseases. The project will be conducted by Northwestern University, a private research institution, over a 5-year period from December 2024 to November 2029.
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