Project Grant R41AI131792

This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $781,502 to Chemia Biosciences, Inc. to develop NATDISCOVERY, a novel computational platform for identifying new non-ribosomal peptide natural product molecules. The overarching goal is to integrate genome mining with computational metabolomics to systematically discover novel natural product small molecules from...

The National Institutes of Health's National Institute of General Medical Sciences awarded Oragenics, Inc. a $769,962 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to support computer-aided design of novel lantibiotics with improved antibiotic properties from August 1, 2021 to July 31, 2022. Specifically, the awardee will investigate the molecular interaction between the lantibiotic mutacin 1140 and its target in silico to rank analogs, synthesize and...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 provides funding to Clue Genetics Inc. for the development of a fungi-focused metabologenomics platform for natural product discovery. The key products and services to be delivered under this 1-year Phase I SBIR project include: Annotating biosynthetic gene clusters (BGCs) from 200 genomes selected from a diverse set of bioactive fungi to uncover new drugs,...

The National Cancer Institute (NCI) awarded a $768,437 project grant under the Cancer Treatment Research program (CFDA 93.395) to the Sanford Burnham Prebys Medical Discovery Institute (SBP) to implement high-throughput screening assays to identify chemical compounds that inhibit the chromatin reader protein SGF29. This target is of interest as it has been identified as a regulator of oncogenic transcription factors aberrantly activated in acute myeloid leukemia (AML), a disease with poor...

The University of Illinois at Urbana-Champaign was awarded a $800,000 Project Grant by the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) to study the development of new methods for catalyzing the synthesis of high-value ring systems prominent in complex natural products, pharmaceutical and agrochemical compounds. The research, led by Professor Scott E. Denmark, aims to use selenium-based catalysts to anneal doubly functionalized reagents (featuring...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development of efficient and accurate methods for identifying novel natural product small molecules from complex mass spectral datasets. The $275,484 award, which began on Sep 1, 2023 and runs through Aug 31, 2024, will enable the grantee, Chemia Biosciences, Inc., to integrate genome mining with computational metabolomics to...

This Project Grant award from the National Center for Advancing Translational Sciences (NCATS), under CFDA Program 93.350, provides $329,272 to Capienda Biotech, LLC to develop a high-throughput kinetic system for small-molecule drug discovery. The goal is to create an innovative instrument that can rapidly characterize the binding kinetics of compounds targeting human cyclin-dependent kinases, which are important oncology targets. This will help medicinal chemists identify drug candidates...

The National Cancer Institute (NCI) awarded a $179,403 Project Grant under the Cancer Treatment Research (CFDA 93.395) program to the University of Nebraska Medical Center (UNMC) to develop and screen novel flupirtine analogue compounds as non-opioid analgesics for treating chemotherapy-induced neuropathic pain (CINP). The 2-year project aims to synthesize and evaluate flupirtine analogues that can effectively relieve CINP while mitigating the liver toxicity concerns associated with the parent...

This $350,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of an integrated workflow that combines computation and experimentation to efficiently expand a metabolomics-enabled drug discovery (MetD4) dataset. The primary focus is on developing neural network models to enable efficient metabolomic characterization of compound libraries, which will aid in...

The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), has awarded Owic Technologies Inc. a $290,670 Project Grant to develop an innovative "Smart Photoelectronics for Electrochemical Synthesis (SPECS)" platform. This platform aims to enable high-throughput electrosynthesis to accelerate the discovery of novel small-molecule drugs for pharmaceutical applications. The project, which runs from Aug 1, 2025...