This Project Grant award, funded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049), supports research at the University of Illinois at Urbana-Champaign led by Professor Scott E. Denmark. The $800,000 award, effective May 1, 2025 through April 30, 2029, aims to develop new catalytic methods for the stereoselective synthesis of pharmaceutically-relevant saturated heterocycles. The research activities focus on three specific aims: (1) catalytic, enantioselective syn-1,2-diamination to construct piperazines and tetrahydroquinazolines; (2) catalytic, enantioselective syn-1,2-oxyamination to construct morpholines and oxazolines; and (3) catalytic, enantioselective, intramolecular 1,2-oxyamination to construct polycyclic oxazolidin-2-ones. This project aims to develop a mechanistic understanding of these catalytic reactions, design chiral catalysts to achieve high stereoselectivity, and demonstrate the generality of the methods across a variety of substrate classes. The research activities provide opportunities for the intellectual and practical training of undergraduates, graduate students, and postdoctoral researchers.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $800.0k | 4/29/25 |