Project Grant R37NS141786
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Maryland, Baltimore a Project Grant of $427,625 on July 17, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research through June 30, 2027, focused on developing a comprehensive toolbox to study proteome plasticity in brain endothelial cells. The research addresses critical gaps in...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $438,625 to the University of California, San Diego under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) on August 7, 2025, for an exploratory research project extending through July 31, 2027. This project grant supports basic and translational neuroscience research aimed at characterizing a novel pro-survival mechanism in neurons exposed...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Alabama at Birmingham $540,236.00 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This Project Grant, effective September 1, 2025, through August 31, 2030, funds research targeting glial HUR (Human Antigen R), an RNA regulator that drives neuroinflammatory responses in acute ischemic stroke. The research aims to...
- Federal Project Grant Award Summary Augusta University Research Institute, Inc. (AURI), doing business as Georgia Health Sciences, received a $462,933 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective January 1, 2026, through December 31, 2030. The award funds investigator-initiated research examining spreading depolarization (SD), a...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Wisconsin–Madison a Project Grant totaling $494,240 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective February 16, 2026, through January 31, 2031. This award funds a five-year research investigation into microRNA (miRNA) degradation mechanisms in post-stroke brain tissue, specifically examining...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Stanford University a $125,685 Project Grant on August 9, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to develop a bioactive material intervention for post-stroke dementia. The research will culminate in the development of an injectable hydrogel embedded with urokinase plasminogen activator (UPA) and plasmid DNA encoding...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $520,025 to the University of Connecticut Health Center on July 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop next-generation RNA inhibitors for ischemic stroke therapy. The research focuses on developing peptide nucleic acid (PNA) analogs, particularly gamma (γ) PNA-based microRNA-141-3p (mir-141-3p)...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Maryland, Baltimore $654,218 on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This five-year project grant, extending through July 31, 2030, supports research investigating the mechanisms and intervention of cyclic GMP-AMP synthase (cGAS) signaling in brain trauma-induced neuroinflammation...
- Federal Grant Award Summary The University of Pennsylvania received a $644,345 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective February 11, 2026, with a completion date of December 31, 2030. The project deliverable is a multicenter randomized controlled trial evaluating MyStroke, a web-based, personalized video-based stroke...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Regents of the University of California, San Francisco a Project Grant totaling $238,410 (awarded August 1, 2025; completion date May 31, 2030) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). This research grant supports an investigator-initiated project examining the protective and harmful mechanisms of acid-base physiology...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Maryland, Baltimore $602,065 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program on March 5, 2026, with a completion date of December 31, 2029. This project grant supports fundamental neuroscience research investigating the molecular mechanisms by which SGLT2 (sodium-glucose cotransporter 2) regulates aquaporin-4 (AQP4) in the context of ischemic stroke. The research seeks to understand how SGLT2 inhibitors reduce acute brain swelling (cerebral edema), a critical factor in stroke outcomes, by examining AQP4 trafficking to cell membranes and disease-associated dysregulation of AQP4 distribution in brain tissue. The primary deliverable is original research employing live-cell imaging, biochemical analysis, and mechanistic investigation of sodium and calcium signaling pathways in post-ischemic astrocytes. Through this work, the research team will generate scientific knowledge regarding the role of sodium influx in activating the sodium-calcium exchanger (NCX1) and its downstream effects on calcium-dependent processes that govern water transport and cellular swelling. Findings from this investigation are intended to advance understanding of stroke pathophysiology and inform therapeutic development targeting brain edema reduction in ischemic stroke patients.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $602.1k | 3/5/26 |