Federal Project Grant Award Summary

The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Pennsylvania $644,345 on February 11, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to develop and evaluate MyStroke, a personalized video-based stroke educational platform. The platform leverages electronic health record data to deliver customized educational content addressing each stroke survivor's specific stroke etiology, individualized risk factors, prescribed medications, and post-stroke lifestyle considerations. This research initiative builds upon preliminary single-center pilot data demonstrating improved patient and caregiver satisfaction and enhanced stroke knowledge retention by integrating engaging video content with post-discharge re-engagement strategies to promote sustained learning and behavior change.

The project, which extends through December 31, 2030, will conduct a multicenter randomized trial to assess MyStroke's impact on both patient-centered outcomes—including stroke knowledge and self-efficacy—and health system-centered outcomes related to post-stroke healthcare utilization and adherence. This intervention addresses a critical gap in stroke care quality, as most stroke survivors lack understanding of their stroke cause, modifiable risk factors, and appropriate symptom recognition protocols. By transforming point-of-care stroke education and establishing sustainable re-education mechanisms following hospital discharge, the research aims to generate evidence supporting adoption of personalized digital health interventions as a standard component of stroke center quality metrics and patient care protocols.