This federal Project Grant award of $499,979 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to uncover astrocyte contributions to neuropathic pain. The project aims to 1) determine how peripheral nerve injury alters dorsal horn astrocyte function, 2) elucidate how targeted interventions control dorsal horn astrocyte function after nerve...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $441,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Duquesne University of the Holy Spirit. The purpose of this 3-year grant, beginning September 2023, is to utilize laboratory data and computational 3-D modeling to analyze the role of the central amygdala in neuropathic pain. Specifically, the project aims to build a proof-of-concept 3-D...
This federal Project Grant award, totaling $279,548.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant will fund research to thoroughly characterize unique sodium currents biophysics in human dorsal root ganglia (DRG) neurons at the University of Texas at Dallas. The research aims to identify novel therapeutic targets and inform the...
This $246,750.00 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of the mesocortical glutamatergic pathway in the development and maintenance of chronic neuropathic pain. The research, conducted by The Trustees of Columbia University in the City of New York, will combine in vivo calcium...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $453,104 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to The University of Texas Southwestern Medical Center to conduct research on ascending spinal pain circuits. The research aims to explore the role of two subtypes of spinal projection neurons, TACR1- and GPR83-expressing neurons, in transmitting chronic pain signals to the brain. The study will...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research to investigate a novel, non-opioid spinal analgesic mechanism for treating high impact chronic pain conditions. The $664,772 award to The University of Texas Southwestern Medical Center aims to evaluate the signaling pathways involved in the activation of the...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, provides $1,612,516.00 in funding to the University of Illinois for a project titled "NICOTINIC ACETYLCHOLINE RECEPTORS IN NEUROPATHIC PAIN" with a performance period from August 1, 2024 to June 30, 2029. The award is made under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, which...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to characterize the role of orexinergic neurons in the spinal cord for treating chronic pain. The $158,512 award to the University of Pittsburgh will fund experiments using two-photon calcium imaging and chemogenetic activation to investigate how orexin signaling in...
This Project Grant award of $597,999.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research focused on understanding the neuronal populations and central sensitization mechanisms underlying mechanical allodynia, a debilitating condition where normally innocuous touch or movement becomes painful after an injury. The key objectives of this 5-year...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $1,525,066 to study the functional connectivity of corticothalamic networks and their role in chronic pain. The 5-year project, with a start date of June 15, 2024, aims to elucidate the mechanisms by which sensory, cognitive, and affective information are integrated...