Project Grant R37CA299857
- Federal Grant Award Summary Cedars-Sinai Medical Center received a $662,610 Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), effective April 1, 2026 through March 31, 2031. The award funds research to develop universal methylated circulating tumor DNA (ctDNA) markers for minimal residual disease (MRD) detection and therapy response prediction in colorectal cancer (CRC). The project addresses critical gaps in...
- Federal Grant Award Summary Cedars-Sinai Medical Center received a $709,677 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394) awarded June 5, 2026, with a completion date of May 31, 2031. The award funds development of quantitative multiparametric Prostate-Specific Membrane Antigen (PSMA) positron emission tomography (PET) magnetic resonance (MR) imaging to improve treatment planning for partial gland ablation of prostate...
- Federal Grant Award Summary Cedars-Sinai Medical Center received a $574,557 Project Grant from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), awarded June 15, 2026, with completion targeted for May 31, 2031. The project integrates life expectancy (LE) estimates into electronic health record (EHR) decision support systems for men with prostate cancer. The research addresses a significant clinical need, as life expectancy is the primary...
- Award Summary Cedars-Sinai Medical Center received a $708,990 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), awarded May 1, 2026, with a completion date of April 30, 2031. The award funds research investigating how interleukin-17 (IL17) cytokine signaling regulates the tumor microenvironment in colorectal cancer (CRC) liver metastasis. The research employs genetic models of IL17 receptor deficiency, IL17 cytokine neutralization,...
- Federal Project Grant Award Summary Cedars-Sinai Medical Center received a $523,670 project grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) to develop and validate an artificial intelligence (AI) model for early detection of pancreatic ductal adenocarcinoma (PDAC) in abdominal computed tomography (CT) scans. The award, obligated on September 12, 2025, with a completion date of August 31, 2029, funds research...
- Federal Grant Award Summary Cedars-Sinai Medical Center received a $191,700 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective September 1, 2025 through August 31, 2028. This award supports research investigating the etiology and tumor characteristics of early-onset pancreatic cancer. The project delivers two primary research products: (1) epidemiological analysis identifying modifiable risk factors associated with...
- Federal Project Grant Award Summary Cedars-Sinai Medical Center received a $695,634 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), awarded May 7, 2026, with completion targeted for April 30, 2031. The award supports research investigating the role of interleukin-27 (IL-27) cytokine signaling and B cell immune responses in hepatocellular carcinoma (HCC) development and progression. The research addresses a critical clinical need, as...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Cedars-Sinai Medical Center a $646,784 Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) on June 16, 2026, with a completion date of May 31, 2031. This research initiative examines the impact of exogenous hormone use on prostate cancer risk, detection, and outcomes within the Veterans Affairs Health System (VAHS). The project builds on prior published findings indicating that men taking...
- Grant Award Summary Cedars-Sinai Medical Center received an $858,798 project grant award dated August 18, 2025, from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) to investigate extracellular vesicle (EV)-enclosed circular RNA (circRNA) mechanisms in prostate cancer immunosuppression. The award, scheduled for completion by July 31, 2027, supports a two-principal-investigator research effort examining how tumor-associated macrophages (TAMs) become...
- Federal Grant Award Summary Albert Einstein College of Medicine received a $431,970 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded July 1, 2026, with completion targeted for June 30, 2028. The award supports development and validation of TDAM (Tumor Microenvironment of Metastasis Doorway Activity-MRI), a non-invasive magnetic resonance imaging technique designed to detect and measure cancer cell...
Award Summary Cedars-Sinai Medical Center received a $743,264 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded on June 23, 2026, with a completion date of May 31, 2031. The grant funds research integrating high-resolution elemental imaging with spatial transcriptomics to analyze metal-based pathways in tumor growth and metastasis. The project addresses a critical gap in understanding dynamic interactions within the tumor microenvironment by combining cutting-edge transcriptomic and elemental profiling techniques to explore metal abundance, form, and transport across different cancer types. The interdisciplinary research team—comprising experts in digital pathology, artificial intelligence, spatial transcriptomics, medical oncology, elemental imaging, and biochemistry—will develop spatial multimodal analytical approaches to identify metal-gene interactions and translate complex molecular data into actionable prognostic markers for improved cancer treatment and metastasis risk assessment. The research directly supports the Cancer Detection and Diagnosis Research program's objectives to develop accurate diagnostic techniques and methods for predicting disease course and treatment response in cancer patients. By establishing novel methods for integrating previously isolated gene and metal analyses, the project advances the program's focus on diagnostic innovation and biomarker discovery. The work is positioned to yield diagnostic tools and biomarkers that enhance early cancer detection capabilities and inform personalized treatment strategies, contributing to the reduction of cancer mortality through improved prognostic precision.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $743.3k | 6/23/26 |